Molecular Characterization of a Novel Germline VHL Mutation by Extensive In Silico Analysis in an Indian Family with Von Hippel-Lindau Disease

Table 1

Summary of prediction scores of in silico methods.

In silico methods	Prediction
SIFT	Deleterious
PROVEAN	Deleterious
PolyPhen 2	Probably damaging
SNAP	Nonneutral
iStable	Decrease protein stability
MUpro (DDG)	Decrease protein stability
MuStab (DDG)	Decrease protein stability
I-Mutant Suite (DDG)	Decrease protein stability