Table of Contents
Hepatitis Research and Treatment
Volume 2010, Article ID 248157, 10 pages
Review Article

Xenobiotic Exposure and Autoimmune Hepatitis

Arkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, 13 Children's Way, Little Rock, AR 72202, USA

Received 10 September 2010; Accepted 9 November 2010

Academic Editor: William Irving

Copyright © 2010 Kathleen M. Gilbert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although genetics contributes to the development of autoimmune diseases, it is clear that “environmental” factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis.