Table of Contents
Hepatitis Research and Treatment
Volume 2010, Article ID 495928, 5 pages
Clinical Study

Optimal Erythrocyte Ribavirin Level to Reduce the Risk of Anemia and Obtain an Early Virological Response in Patients with Chronic Hepatitis C Caused by Genotype 1b Infection

1Pharmacy Practice and Sciences, Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
2Research Center for Liver Diseases, The Kitasato Institute Hospital, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
3Department of Internal Medicine, The Kitasato Institute Medical Center Hospital, Kitasato University, 6-100 Arai, Kitamoto-shi, Saitama 364-8501, Japan

Received 13 May 2010; Revised 28 July 2010; Accepted 4 August 2010

Academic Editor: Tatehiro Kagawa

Copyright © 2010 Rie Kubota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. To determine whether the erythrocyte phosphorylated ribavirin (RBV) level might be a useful index of EVR and risk of anemia and to determine the optimal dose of RBV in 24 patients with hepatitis C with pegylated interferon and RBV. Methodology. The RBV level was measured by a high-performance liquid chromatography. Results and Conclusion. In patients aged 50 years or over, a negative correlation ( 𝑟 = − 0 . 5 4 8 , 𝑃 < . 0 5 ) was observed between the RBV level at week 2 and rate of Hb reduction ( Δ H b ) at week 4. The Δ H b at week 4 was significantly greater in patients with RBV levels of ≥800  𝜇 M ( − 2 5 . 5 ± 1 0 . 1 %) than in patients with RBV levels <800  𝜇 M ( − 1 5 . 6 ± 7 . 7 %). None of the patients with RBV levels <600  𝜇 M at week 2 achieved EVR and SVR. Thus the optimal levels of erythrocyte phosphorylated RBV at week 2 of therapy in order to achieve EVR without anemia seemed to be 600–800  𝜇 M .