Hepatitis Research and Treatment / 2010 / Article / Tab 1

Review Article

Can Engineered “Designer” T Cells Outsmart Chronic Hepatitis B?

Table 1

Advantages and disadvantages of CAR redirected T cell therapy.

AdvantagesDisadvantages

MHC-independent antigen targetingempirical testing of newly generated CARs required
High affinity bindingoptimal T cell-to-target cell spacing distance required for T cell activation
Allows production of high numbers of antigen-specific, patient-derived T cellsindividual engineering of patient’s T cells necessary
allows redirecting and T cellsshort-term persistence of engineered T cells in vivo
redirection towards a broad variety of targets possibleT cell expansion may reduce reactivity
T cell expansion upon antigen engagementantigen cross-reactivity increases risk of “off-target” activation and autoimmunity
Repetitive killing possiblesoluble antigen may block T cell activation

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