Table of Contents
Hepatitis Research and Treatment
Volume 2010, Article ID 971095, 6 pages
http://dx.doi.org/10.1155/2010/971095
Research Article

Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells

1Laboratorio de Inmunobiología, Departmento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma (UNAM), Ciudad Universitaria, CP 04510, DF, Mexico
2Servicio de Gastroenterología, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Avenida Universidad 2050, Viveros Coyoacan, CP 04526, DF, Mexico
3Unidad de Investigación, Instituto de Oftalmología “Conde de Valenciana”, Chimalpopoca 14, CP 06800, DF, Mexico
4Departamento Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, CP 04510, DF, Mexico
5Departamento Biologìa Celular, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Tlalpan, CP 14080, DF, Mexico

Received 11 August 2009; Revised 18 December 2009; Accepted 15 February 2010

Academic Editor: Alessandro Antonelli

Copyright © 2010 Luis A. Salazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b. 5–12% of patients with chronic HCV infection have hypothyroidism. We evaluated the role of these cytokines in this patients by determining serum concentration of TsH, T3, free T4, IL2, IL10, IL12, IL17, TGF-b, anti-TG, TPO, CCP, GBM, and cardiolipin antibodies in 87 chronically noninterferon treated HCV-infected patients. 20 patients (group A) had elevated TsH values (>5  UI/ml) whereas the remaining 67 (group B) had normal values. The percentage of anti-TPO, TG, GBM, and cardiolipin antibodies in group A patients (33%, 41%, 5% and 5%, resp.) as well as IL17, IL2 and TGF-b concentrations ( pg/ml, pg/ml, and pg/ml, resp.) were significantly higher than group B. Abnormal Th17 regulation mediated by IL-2 and low TGF-b concentrations is associated with hypothyroidism in chronically-infected HCV patients.