Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Table 3

Distribution of TP53/CTNNB1 mutations and clinicopathological data according to HBV infection status.

	Overt HBV infections 𝑛=13*	Occult HBV infections 𝑛=5	Negative for both HBsAg and HBV DNA 𝑛=5	Total
TP53
R249S	5	0	0	5
Other mutation	1	1	0	2
WT	7	4	5	16
CTNNB1
MUT	3	2	0	5
WT	7	3	4	14
HCV	2	1	1	4
Sex
M	13	4	3	20
F	0	1	2	3
Grade
≥3	7	2	2	11
<3	6	3	3	12
HCC morphology
Trabecular	11	5	2	18
Pleiomorphic	2	0	1	3
Pseudoglandular	1	0	1	2
Necrosis	1	0	2	3
Age	43.2±12.12	51.4±15.2	49.4±13.7

WT = wildtype, MUT = mutant, *three HBV-DNA positive cases with missing data on serology were omitted in this table, ^†CTNNB1 was not amplifiable in four cases, three cases with overt HBV infection and one HBV-negative case.