Hepatitis Research and Treatment / 2011 / Article / Tab 3

Clinical Study

Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection

Table 3

Comparison of cut-off points, sensitivity, specificity, PPV, and NPV in different studies.

Adams et al. [12]Leroy et al. [16]Halfon et al. [17]Becker et al. [1]Guechot et al. [14]This study

Patients number10418035639151280
F0/F1/F2/F3/F4 (%)16/27/34/7/168/41/22/14/144/55/26/11/416/34/15/16/197/45/18/15/1515/31/25/8/20

For significant fibrosis
 Cut-off0.50.50.320.550.50.34
 Sensitivity63%54%77%82%77%67%
 Specificity89%84%63%65%70%56%
 Positive predictive value/78%59%70%71%64%
 Negative predictive value/64%80%78%77%56%

For sever fibrosis
 Cut-off/0.840.530.80.60.61
 Sensitivity/47%78%/80%82%
 Specificity/90%72%77%70%86%
 Positive predictive value/65%32%62%54%70%
 Negative predictive value/81%95%/89%92%

For cirrhosis
 Cut-off0.84/0.61/0.750.84
 Sensitivity71%/92%/86%100
 Specificity89%/72%/74%97%
 Positive predictive value//11%/37%89%
 Negative predictive value/100%/97%100

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