Table of Contents
Hepatitis Research and Treatment
Volume 2012, Article ID 324090, 4 pages
http://dx.doi.org/10.1155/2012/324090
Research Article

Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia

1Department of Hepatology, Infectology Center of Latvia, Riga, Linezera Street 3, 1006 Riga, Latvia
2Division of Doctoral Studies, Riga Stradins University, Dzirciema Street 16, 1007 Riga, Latvia
3Department of Infectology and Dermatology, Riga Stradins University, Dzirciema Street 16, 1007 Riga, Latvia
4Faculty of Continuing Education, Riga Stradins University, Dzirciema Street 16, 1007 Riga, Latvia

Received 2 November 2011; Revised 2 February 2012; Accepted 25 February 2012

Academic Editor: Andre Castro Lyra

Copyright © 2012 Ieva Tolmane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Lavanchy, “The global burden of hepatitis C,” Liver International, vol. 29, no. 1, pp. 74–81, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Tolmane, B. Rozentale, J. Keiss, F. Arsa, and A. Zvaigzne, “Prevalence of viral hepatitis C in Latvia: a population based study,” Medicina, vol. 47, no. 10, pp. 532–535, 2011. View at Google Scholar
  3. T. Heintges and J. R. Wands, “Hepatitis C virus: epidemiology and transmission,” Hepatology, vol. 26, no. 3, pp. 521–526, 1997. View at Google Scholar · View at Scopus
  4. B. Lettmeier, N. Mühlberger, R. Schwarzer et al., “Market uptake of new antiviral drugs for the treatment of hepatitis C,” Journal of Hepatology, vol. 49, no. 4, pp. 528–536, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. V. Kotenko, G. Gallagher, V. V. Baurin et al., “IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex,” Nature Immunology, vol. 4, no. 1, pp. 69–77, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Sheppard, W. Kindsvogel, W. Xu et al., “IL-28, IL-29 and their class II cytokine receptor IL-28R,” Nature Immunology, vol. 4, no. 1, pp. 63–68, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. J. Thompson, A. J. Muir, M. S. Sulkowski et al., “Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus,” Gastroenterology, vol. 139, no. 1, pp. 120–129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. W. Fried, M. L. Shiffman, K. Rajender Reddy et al., “Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection,” New England Journal of Medicine, vol. 347, no. 13, pp. 975–982, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. M. P. Manns, J. G. McHutchison, S. C. Gordon et al., “Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial,” The Lancet, vol. 358, no. 9286, pp. 958–965, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. S. J. Hadziyannis, H. Sette, T. R. Morgan et al., “Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose,” Annals of Internal Medicine, vol. 140, no. 5, pp. 346–355, 2004. View at Google Scholar · View at Scopus
  11. A. Par, P. Kisfali, and B. Melegh, “Cytokine (IL-10, IL-28B and LT-A) gene polymorphisms in chronic hepatitis C virus infection,” The International Journal of Clinical and Experimental Medicine, vol. 5, no. 1, pp. 9–19, 2011. View at Google Scholar