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Hepatitis Research and Treatment
Volume 2012 (2012), Article ID 493219, 6 pages
Review Article

The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

Digestive Disease Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Ave, Tehran 14114, Iran

Received 18 May 2012; Revised 13 September 2012; Accepted 1 October 2012

Academic Editor: Piero Luigi Almasio

Copyright © 2012 Sirous Tayebi and Ashraf Mohamadkhani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association.