Table of Contents
Hepatitis Research and Treatment
Volume 2012, Article ID 619609, 4 pages
http://dx.doi.org/10.1155/2012/619609
Research Article

Neopterin as a Marker of Response to Antiviral Therapy in Hepatitis C Virus Patients

1Psychiatry and Inflammation Program, Department of Psychiatry, Tufts Medical Center, Tufts University, Boston, MA 02459, USA
2Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University, Boston, MA 02459, USA
3Hepatology Clinic, Division of Gastroenterology, Department of Medicine, Tufts Medical Center, Tufts University, Boston, MA 02459, USA

Received 20 February 2012; Revised 11 April 2012; Accepted 21 April 2012

Academic Editor: Savino Bruno

Copyright © 2012 Gregory F. Oxenkrug et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. W. Shepard, L. Finelli, and M. J. Alter, “Global epidemiology of hepatitis C virus infection,” Lancet Infectious Diseases, vol. 5, no. 9, pp. 558–567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. G. R. Foster, C. Hézode, J. P. Bronowicki et al., “Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections,” Gastroenterology, vol. 141, no. 3, pp. 881–889, 2011. View at Google Scholar
  3. A. Mangia, A. J. Thompson, R. Santoro et al., “An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response,” Gastroenterology, vol. 139, no. 3, pp. 821–827, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Sarasin-Filipowicz, E. J. Oakeley, F. H. Duong et al., “Interferon signaling and treatment outcome in chronic hepatitis C,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 19, pp. 7034–7039, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. T. Dill, F. Duong, J. Vogt et al., “Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C,” Gastroenterology, vol. 140, no. 3, pp. 1021–1031, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Fuchs, P. Avanzas, R. Arroyo-Espliguero, M. Jenny, L. Consuegra-Sanchez, and J. C. Kaski, “The role of neopterin in atherogenesis and cardiovascular risk assessment,” Current Medicinal Chemistry, vol. 16, no. 35, pp. 4644–4653, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Oxenkrug, K. Tucker, P. Requintina, and P. Summergrad, “Neopterin, a marker of interferon-gamma-inducible inflammation, correlates with pyridoxal-5-phosphate, waist circumference, HDL cholesterol, insulin resistance and mortality risk in adult Boston community dwellers of Puerto Rican origin,” American Journal of Neuroprotection and Neuroregeneration, vol. 3, no. 1, pp. 48–52, 2011. View at Google Scholar
  8. D. Fuchs, G. Norkrans, R. Wejstal et al., “Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b,” The European Journal of Medicine, vol. 1, no. 4, pp. 196–200, 1992. View at Google Scholar · View at Scopus