Table of Contents
Hepatitis Research and Treatment
Volume 2012, Article ID 947575, 8 pages
Review Article

Antioxidant Therapy in Nonalcoholic Steatohepatitis

1Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Alkhoudh, Muscat 123, Oman
2Department of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC, Canada H3A 1A1

Received 20 July 2012; Revised 18 September 2012; Accepted 9 October 2012

Academic Editor: David Hoffman Van Thiel

Copyright © 2012 Said A. Al-Busafi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.