Hepatitis Research and Treatment

Hepatitis Research and Treatment / 2013 / Article

Clinical Study | Open Access

Volume 2013 |Article ID 479639 | https://doi.org/10.1155/2013/479639

Maja Thiele, Gro Askgaard, Hans B. Timm, Ole Hamberg, Lise L. Gluud, "Predictors of Health-Related Quality of Life in Outpatients with Cirrhosis: Results from a Prospective Cohort", Hepatitis Research and Treatment, vol. 2013, Article ID 479639, 6 pages, 2013. https://doi.org/10.1155/2013/479639

Predictors of Health-Related Quality of Life in Outpatients with Cirrhosis: Results from a Prospective Cohort

Academic Editor: Yoichi Hiasa
Received10 Aug 2013
Revised21 Nov 2013
Accepted24 Nov 2013
Published22 Dec 2013

Abstract

Background. Cirrhosis may lead to a poor health-related quality of life (HRQOL), which should be taken into consideration when addressing the cirrhotic outpatient. Methods. Prospective cohort study evaluating predictors of HRQOL in outpatients with cirrhosis. Patients with overt hepatic encephalopathy at baseline were excluded. HRQOL was evaluated at baseline using the six point Chronic Liver Disease Questionnaire. Predictors of low quality of life scores (<4 points) and mortality were analyzed using multivariable logistic regression. Results. In total, 92 patients were included (mean age 61 years, 59% male). Nineteen patients died (mean duration of follow-up 20 months). The mean Child-Pugh score was 6.9. Twenty percent had a poor HRQOL judged by the Chronic Liver Disease Questionnaire score and 45% had covert hepatic encephalopathy. The only predictors of poor HRQOL were the Child-Pugh score ( ), nonalcoholic etiology of cirrhosis ( ), and body mass index ( ). The body mass index predicted poor HRQOL independently of the presence of ascites and albumin level. Conclusions. The body mass index was associated with a low HRQOL. This suggests that malnutrition may be an important target in the management of patients with cirrhosis.

1. Introduction

The prognosis of cirrhosis has improved following the development of a number of effective interventions [13]. The improvements include the management of gastrointestinal bleeding, hepatorenal syndrome, spontaneous bacterial peritonitis, hepatocellular carcinoma, and hepatic encephalopathy (HE) [48]. The health-related quality of life (HRQOL) is therefore becoming increasingly important [913]. Most quality of life studies have used generic questionnaires, which allow for comparisons between different groups of patients. These questionnaires will provide an overall picture of the wellbeing of participants. Patients with cirrhosis have specific somatic and cognitive symptoms that may affect their HRQOL [12, 14, 15]. These symptoms may not be captured by generic scales [9, 13, 16, 17]. Questionnaires specifically for patients with chronic liver disease have therefore been developed [14, 18].

Identifying factors associated with HRQOL may help improve patient care and guide future research [12]. This is especially the case for long-term care in an outpatient setting. We therefore performed a prospective cohort study aimed at investigating the prognosis and predictors of HRQOL in patients with cirrhosis followed up at an outpatient setting.

2. Materials and Methods

2.1. Included Subjects

From February 2008 to May 2012 we conducted a prospective cohort study on patients with cirrhosis recruited from two Danish liver outpatient clinics. Patients were eligible for inclusion if they had histological or clinical cirrhosis and were able to read Danish. Patients with overt HE (West Haven Criteria Grades 2 to 4) and concurrent malignancy were excluded. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the Danish ethics committee.

Patients were identified at their regular visits to the participating clinics or through the Danish case-mix system of diagnostic codes (dkDRG; Diagnosis Related Groups, based on the ICD-10 classification system). Patients identified electronically were invited to participate by telephone. Patients who agreed to participate completed a written informed consent at the inclusion visit.

At inclusion, demographic data, the patient history, and medication were recorded. A full physical examination and a broad screening panel of tests (including liver function tests, haematology, creatinine, and electrolytes) were performed. The Child-Pugh score was calculated. Evidence of covert HE [17] was evaluated clinically and using the continuous reaction time test (CRT), which is a validated computerized psychometric test [1924]. The test records reaction times to sound stimuli. Test results are expressed as reaction time percentiles (10, 50, and 90). An index value for the reaction time variance (index value = 50 percentile/90 percentile − 10 percentile) is calculated. Lower index values indicate higher reaction time variance with values below 1.900 suggesting HE in patients with cirrhosis.

HRQOL was evaluated using the six-point, 29-item Chronic Liver Disease Questionnaire (CLDQ) [18]. The questionnaire covers six domains: abdominal symptoms, fatigue, worry, activity, and systemic symptoms. The questionnaire was validated in a pilot study cohort of 15 patients (after backward and forward translation into Danish).

2.2. Statistical Analyses

Patient characteristics were summarized as proportions with means and standard deviations/range. The CLDQ score was classed as low (<4) or high (4–6). Predictors of CLDQ scores and mortality were analyzed using binary logistic regression. Multivariable analyses were performed using backward elimination. The predictors were age, gender, body mass index (BMI), etiology of liver cirrhosis, employment, marital status, comorbidities, previous hepatic decompensation, covert hepatic encephalopathy, Child-Pugh score, ascites, ongoing alcohol abuse, albumin, and hyponatremia. Statistical analyses were performed using STATA version 12 (Stata Corp., College Station, Texas, US).

3. Results

3.1. Patient Characteristics

A total of 92 patients were included and followed for a mean duration of 20 months (range 3 to 52 months). Four patients withdrew their consent regarding the CRT test and the HRQOL questionnaire. Five patients did not complete the CRT test or the HRQOL scores because they had to be hospitalized due to worsening of their underlying liver disease. All 92 patients continued in the follow-up cohort and were included in the outcome analysis.

The mean age of included patients was 61 (SD 8.7; range 41 to 83 years) and 54 (59%) were men. The mean body mass index was 24 (SD 4.0; range 16 to 35). Most patients had cirrhosis due to alcoholic liver disease (Table 1). The remaining patients had autoimmune liver diseases (4), nonalcoholic steatohepatitis (2), chronic hepatitis C infection (3), hemochromatosis (1), or cryptogenic cirrhosis (3).


VariableMean ± SD (range)
(%)

Followup (months)19.9 ± 16.0 (3–52)
Male gender54 (59)
Employed14 (15)
Married or similar 51 (55)
Age (years)61.5 ± 8.7 (41–83)
Alcoholic liver cirrhosis79 (86)
Child-Pugh score6.8 ± 1.6 (5–12)
Child-Pugh class A/B/C46/38/8
International normalized ratio1.28 ± 0.3 (0.9–3.1)
ALT (international units)32 ± 25 (3–163)
Creatinine ( mol/L)86 ± 35 (43–221)
Sodium (mmol/L)137 ± 6 (101–146)
Ammonia ( mol/L)37 ± 34 (0–91)
Albumin (g/L)39 ± 6 (27–50)
Ongoing alcohol abuse39 (42)
Ascites present26 (28)
Prior decompensation
 Ascites59 (64)
 Hepatic encephalopathy21 (23)
 Varices 41 (45)
 Prior variceal bleeding13 (14)
Comorbidities
 Lung disease11 (12)
 Heart disease*30 (33)
 Kidney disease12 (13)
 Diabetes18 (20)
 Prior malignancy8 (9)

includes arterial hypertension and atrial fibrillation. ALT: alanine
aminotransferase.

Fifty-two percent of the patients were classed as Child-Pugh class A. The mean Child-Pugh score was 6.9 (SD 1.7; range 5 to 12). Seventy-seven patients had clinical signs of decompensation prior to inclusion. At baseline, 26 patients (28%) had ascites and 41 patients (45%) were diagnosed as having covert HE. Sixty-one patients were treated with lactulose, 61 with beta-blockers, 57 with loop diuretics, and 35 with spironolactone. Eighty-three received vitamins.

During followup, 19 patients died (21%), including seven classed as Child-Pugh class A at baseline (Table 2). Most patients died from liver related causes. Even though patients with concurrent malignancy were excluded, six fatalities were due to cancer disease. Four of these were hepatocellular carcinoma, stressing the importance of this cancer even in a population consisting largely of patients with alcoholic cirrhosis. One patient underwent successful liver transplantation and two patients received a transjugular intrahepatic portosystemic shunt. Spontaneous bacterial peritonitis was diagnosed in six patients and 34 developed other bacterial infections that required hospitalization. Seventeen patients were admitted with upper gastrointestinal bleeding, 25 developed overt HE, and six developed hepatorenal syndrome. Seven patients were admitted with an ischemic stroke (Table 3).


CausesChild-Pugh class

Gastrointestinal bleeding (1), variceal bleeding (2), hepatorenal syndrome (1), metastatic oropharynx cancer (1), and HCC (2).A
Metastatic lung cancer (2), progressive liver failure (2), HCC (1), sepsis (1), and unknown (1).B
Gastrointestinal bleeding (1), progressive liver failure (2), HRS (1), and HCC (1).C

HCC: hepatocellular carcinoma; HRS: hepatorenal syndrome.

Event (%)

Death19 (21)
Transplantation1 (1)
TIPS2 (2)
Hepatic encephalopathy25 (27)
Hepatorenal syndrome6 (7)
Nonvariceal gastrointestinal bleeding17 (18)
Variceal bleeding5 (5)
Hepatocellular carcinoma4 (4)
Spontaneous bacterial peritonitis6
Bacterial infections34
Other events, requiring hospitalisation25

TIPS: transjugular intrahepatic portosystemic shunt.

In univariable logistic regression, the Child-Pugh score and albumin predicted mortality (regression coefficient ( ) 0.362; and ;  ). None of the remaining variables were associated with mortality (Table 4). In multivariable regression analysis, the Child-Pugh score remained the only predictor of mortality after backward elimination.


VariableMortalityCLDQ score < 4
Regression coefficient valueRegression coefficient value

Age0.0170.576−0.0200.507
Gender−0.5800.264−0.9450.091
Body mass index−0.1470.083−0.2020.023
Employment−0.4050.619−0.5390.519
Marital status0.0950.855−0.8410.133
Nonalcoholic etiology of cirrhosis−0.8910.196−2.3430.009
Comorbidities
 Heart disease0.5980.2670.2700.634
 Pulmonary disease−0.2190.798
 Renal disease0.7580.263−0.5150.537
 Diabetes0.5570.360−0.6440.437
 Previous malignancy0.9210.238−0.3480.763
Previous hepatic decompensation
 Ascites0.4590.425−0.2700.634
 Hepatic encephalopathy0.6420.267−0.7070.315
 Esophageal varices0.1180.820−0.8790.140
Child-Pugh score0.3620.0180.4540.013
Ascites at inclusion−0.1420.8070.7520.199
Minimal hepatic encephalopathy−0.0130.9820.1600.778
Hyponatremia−0.0020.679−0.0030.521
Albumin−0.1290.012−0.0830.109
Ongoing alcohol abuse−0.0640.903−0.4910.379

CLDQ: Chronic Liver Disease Questionnaire.
Results in bold refers to statistically significant predictors of mortality and CLDQ.

The mean CLDQ score was 4.4 (SD 0.7; range: 2.8 to 5.9). Eighteen patients (20%) had low CLDQ scores. The most frequent complaint was fatigue (mean score 3.7; SD 1.0; range 1 to 6 points) and most commonly patients had trouble lifting or carrying heavy objects (Figure 1). Univariable analysis found that patients with a low CDLQ score were more likely to have a high Child-Pugh score ( ;  ), other causes of cirrhosis than alcohol ( ;  ), and a low BMI ( ;  ). The association with BMI was independent of the presence of ascites, low albumin or the Child-Pugh score. None of the remaining variables were associated with low CLDQ scores (Table 4). In multivariable analysis, the Child-Pugh score and etiology other than alcohol were independent predictors of CLDQ scores ( ;  and ;  ) but not BMI ( ; ).

4. Discussion

This prospective cohort study showed that one in five outpatients with cirrhosis had a low health-related quality of life. The finding was surprising considering the high proportion of patients without signs of hepatic decompensation. The severity of the underlying liver disease predicted both poor HRQOL and mortality. The nutritional status estimated by the BMI was a predictor of HRQOL, independent of the presence of ascites or low albumin. Patients with a low BMI were more likely to have a low HRQOL.

The relatively small sample size is the main limitation of the present study and may explain why the Child-Pugh score, non-alcoholic etiology, and BMI were the only predictors of quality of life. However, our results concur with studies showing that the Child-Pugh score is associated with the quality of life. Our results concur with studies showing that the Child-Pugh score is associated with the quality of life [12, 14]. The association between a low BMI and a low quality of life has been identified for patients with other disease categories but not for patients with cirrhosis [25, 26]. The association between a low BMI and a low quality of life score was independent of the severity of the underlying liver disease, presence of ascites, and albumin level. This suggests that interventions aiming at an improved overall nutritional status of cirrhotic patients may improve their quality of life. We recommend following the International Society for Hepatic Encephalopathy and Nitrogen Metabolism consensus statement regarding nutritional management of hepatic encephalopathy in patients with cirrhosis [27]. Frequent small meals rich in vegetables and dairy protein supplemented with a night time snack of complex carbohydrates may be of benefit to all cirrhotics with a BMI below 25. Accordingly, studies on patients with cirrhosis have found a beneficial effect on the HRQOL of branched chain amino acids and late evening nutritional supplements, which resulted in minor weight gains [2830].

Our results do not allow for a recommendation of the optimal BMI in chronic liver disease, neither does our study offer a causal explanation of the association between lower BMI and low HRQOL. A low BMI may cause low HRQOL, for example, due to decreased resilience. Alternatively, the body weight of patients with a low HRQOL may decrease, for example, due to inadequate food intake. However, as excess body weight has been associated with increased risk of HCC in chronic liver disease and disease progression in alcoholic liver disease, it can be speculated that BMI in patients with cirrhosis should not exceed 25 [31, 32]. Likewise, avoiding obesity associated with coronary heart disease and diabetes is of great importance, especially as the incidence of NASH cirrhosis is increasing.

The CLDQ is developed and validated in cohorts of patients with all types of liver diseases [18]. We did however find that patients with nonalcoholic etiologies of liver disease had significantly lower HRQOL than patients with alcoholic cirrhosis. The reason for this is unclear and opposes prior findings [14].

In agreement with previous studies, 60% of included patients had covert HE [33, 34]. We found no association between CLDQ scores and HE as judged by the continuous reaction times. Unlike studies on overt HE [9, 13, 16, 35], the evidence on the impact of covert HE on HRQOL is less conclusive [9, 13, 3639]. However, we cannot exclude that our study would have generated different results if the sample size was larger.

Although most of the included patients had compensated liver disease at baseline, the prognosis was severe. Twenty-one percent of included patients died. Seven of nineteen deaths occurred in patients who were classed as Child-Pugh group A. Most of these patients had previous signs of decompensated liver disease with ascites, variceal bleeding, spontaneous bacterial peritonitis, or overt HE. Our results support the theory that decompensating events as well as Child-Pugh scores predict long-term prognosis in cirrhosis [3]. The increased risk of infections concurs with previous evidence [40, 41]. The relatively high number of strokes may reflect the coagulopathy that is seen in chronic liver disease [42].

In conclusion, this study found that the prognosis of patients with cirrhosis is severe. The finding suggests that these patients should be followed at outpatient clinics as even patients with a low Child-Pugh class may benefit from regular visits. Additional studies are needed to identify the most efficient management strategies in order to improve the prognosis as well as the quality of life. Interventions directed against malnutrition may help achieve this goal.

Abbreviations

BMI:Body mass index
CLDQ:Chronic Liver Disease Questionnaire
CRT:Continuous reaction time test
HE:Hepatic encephalopathy
HRQOL:Health-related quality of life.

Conflict of Interests

There is no conflict of interests.

Authors’ Contribution

Maja Thiele is the gurantator of the paper. Conceptualization: Lise Lotte Gluud, Ole Hamberg, Hans B. Timm. Recruitment: All authors. Data collection: Gro Askgaard, Hans B. Timm, Maja Thiele. Statistical analyses: Maja Thiele, Lise Lotte Gluud. Drafted the paper: Maja Thiele, Lise Lotte Gluud, Gro Askgaard. All authors have approved of the final version of the paper.

Acknowledgments

The authors would like to thank Mette Munk Lauridsen, M.D., for advice regarding the continuous reaction time test and the specialist nurses Kirsten Passow, Hanne Bennick, Birte Röttig, and Kirsten Larsen for their dedicated work, which facilitated the conduct of the present study. The study was supported by a working grant from the START Fund, Copenhagen University Hospital Gentofte. Results from the study were presented at the 15th ISHEN Symposium (International Society for Hepatic Encephalopathy and Nitrogen Metabolism) and at the 2012 annual meeting of the Danish Society of Gastroenterology and Hepatology.

References

  1. A. Propst, T. Propst, G. Zangerl, D. Ofner, G. Judmaier, and W. Vogel, “Prognosis and life expectancy in chronic liver disease,” Digestive Diseases and Sciences, vol. 40, no. 8, pp. 1805–1815, 1995. View at: Publisher Site | Google Scholar
  2. H. T. Sørensen, A. M. Thulstrup, L. Mellemkjar et al., “Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark,” Journal of Clinical Epidemiology, vol. 56, no. 1, pp. 88–93, 2003. View at: Publisher Site | Google Scholar
  3. G. D'Amico, G. Garcia-Tsao, and L. Pagliaro, “Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies,” Journal of Hepatology, vol. 44, no. 1, pp. 217–231, 2006. View at: Publisher Site | Google Scholar
  4. M. Thiele, A. Krag, U. Rohde, and L. L. Gluud, “Meta-analysis: banding ligation and medical interventions for the prevention of rebleeding from oesophageal varices,” Alimentary Pharmacology and Therapeutics, vol. 35, no. 10, pp. 1155–1165, 2012. View at: Publisher Site | Google Scholar
  5. L. L. Gluud, K. Christensen, E. Christensen, and A. Krag, “Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome,” Hepatology, vol. 51, no. 2, pp. 576–584, 2010. View at: Publisher Site | Google Scholar
  6. R. Wiest, A. Krag, and A. Gerbes, “Spontaneous bacterial peritonitis: recent guidelines and beyond,” Gut, vol. 61, no. 2, pp. 297–310, 2012. View at: Publisher Site | Google Scholar
  7. EASL-EORTC, “EASL-EORTC Clinical Practice Guidelines: management of hepatocellular carcinoma,” Journal of Hepatology, vol. 56, pp. 908–943, 2012. View at: Google Scholar
  8. J. S. Bajaj, “Review article: the modern management of hepatic encephalopathy,” Alimentary Pharmacology and Therapeutics, vol. 31, no. 5, pp. 537–547, 2010. View at: Publisher Site | Google Scholar
  9. M. R. Arguedas, T. G. DeLawrence, and B. M. McGuire, “Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis,” Digestive Diseases and Sciences, vol. 48, no. 8, pp. 1622–1626, 2003. View at: Publisher Site | Google Scholar
  10. E. Fritz and J. Hammer, “Gastrointestinal symptoms in patients with liver cirrhosis are linked to impaired quality of life and psychological distress,” European Journal of Gastroenterology and Hepatology, vol. 21, no. 4, pp. 460–465, 2009. View at: Publisher Site | Google Scholar
  11. M. Holecek, “Three targets of branched-chain amino acid supplementation in the treatment of liver disease,” Nutrition, vol. 26, no. 5, pp. 482–490, 2010. View at: Publisher Site | Google Scholar
  12. G. Marchesini, G. Bianchi, P. Amodio et al., “Factors associated with poor health-related quality of life of patients with cirrhosis,” Gastroenterology, vol. 120, no. 1, pp. 170–178, 2001. View at: Google Scholar
  13. I. Les, E. Doval, M. Flavia et al., “Quality of life in cirrhosis is related to potentially treatable factors,” European Journal of Gastroenterology & Hepatology, vol. 22, pp. 221–227, 2010. View at: Google Scholar
  14. Z. M. Younossi, N. Boparai, L. L. Price, M. L. Kiwi, M. McCormick, and G. Guyatt, “Health-related quality of life in chronic liver disease: the impact of type and severity of disease,” American Journal of Gastroenterology, vol. 96, no. 7, pp. 2199–2205, 2001. View at: Publisher Site | Google Scholar
  15. E. Kalaitzakis, M. Simrén, R. Olsson et al., “Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of life,” Scandinavian Journal of Gastroenterology, vol. 41, no. 12, pp. 1464–1472, 2006. View at: Publisher Site | Google Scholar
  16. Z.-J. Bao, D.-K. Qiu, X. Ma et al., “Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy,” World Journal of Gastroenterology, vol. 13, no. 21, pp. 3003–3008, 2007. View at: Google Scholar
  17. J. S. Bajaj, J. Cordoba, K. D. Mullen et al., “Review article: the design of clinical trials in hepatic encephalopathy—an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement,” Alimentary Pharmacology and Therapeutics, vol. 33, no. 7, pp. 739–747, 2011. View at: Publisher Site | Google Scholar
  18. Z. M. Younossi, G. Guyatt, M. Kiwi, N. Boparai, and D. King, “Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease,” Gut, vol. 45, no. 2, pp. 295–300, 1999. View at: Google Scholar
  19. S.-E. Christensen, P. Elsass, and H. Vilstrup, “Number connection test and continuous reaction times in non-encephalopathic patients: a comparative study,” Journal of Applied Toxicology, vol. 1, no. 5, pp. 262–263, 1981. View at: Google Scholar
  20. P. Elsass, “Continuous reaction times in cerebral dysfunction,” Acta Neurologica Scandinavica, vol. 73, no. 3, pp. 225–246, 1986. View at: Google Scholar
  21. P. Elsass, S. E. Christensen, E. L. Mortensen, and H. Vilstrup, “Discrimination between organic and hepatic encephalopathy by means of continuous reaction times,” Liver, vol. 5, no. 1, pp. 29–34, 1985. View at: Google Scholar
  22. P. Elsass, S. E. Christensen, and L. Ranek, “Continuous reaction time in patients with hepatic encephalopathy. A quantitative measure of changes in consciousness,” Scandinavian Journal of Gastroenterology, vol. 16, no. 3, pp. 441–447, 1981. View at: Google Scholar
  23. M. M. Lauridsen, H. Gronbaek, E. B. Naeser et al., “Gender and age effects on the continuous reaction times method in volunteers and patients with cirrhosis,” Metabolic Brain Disease, vol. 27, no. 4, pp. 559–565, 2012. View at: Publisher Site | Google Scholar
  24. M. M. Lauridsen, P. Jepsen, and H. Vilstrup, “Critical flicker frequency and continuous reaction times for the diagnosis of minimal hepatic encephalopathy. A comparative study of 154 patients with liver disease,” Metabolic Brain Disease, vol. 26, no. 2, pp. 135–139, 2011. View at: Publisher Site | Google Scholar
  25. J. C. Hoekstra, J. H. M. Goosen, G. S. de Wolf, and C. C. P. M. Verheyen, “Effectiveness of multidisciplinary nutritional care on nutritional intake, nutritional status and quality of life in patients with hip fractures: a controlled prospective cohort study,” Clinical Nutrition, vol. 30, no. 4, pp. 455–461, 2011. View at: Publisher Site | Google Scholar
  26. A. Nourissat, M. P. Vasson, Y. Merrouche et al., “Relationship between nutritional status and quality of life in patients with cancer,” European Journal of Cancer, vol. 44, no. 9, pp. 1238–1242, 2008. View at: Publisher Site | Google Scholar
  27. P. Amodio, C. Bemeur, R. Butterworth et al., “The nutritional management of hepatic encephalopathy in patients with cirrhosis: international society for hepatic encephalopathy and nitrogen metabolism consensus,” Hepatology, vol. 58, pp. 325–336, 2013. View at: Google Scholar
  28. Y. Nakaya, K. Okita, K. Suzuki et al., “BCAA-enriched snack improves nutritional state of cirrhosis,” Nutrition, vol. 23, no. 2, pp. 113–120, 2007. View at: Publisher Site | Google Scholar
  29. G. Marchesini, G. Bianchi, M. Merli et al., “Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial,” Gastroenterology, vol. 124, no. 7, pp. 1792–1801, 2003. View at: Publisher Site | Google Scholar
  30. L. D. Plank, E. J. Gane, S. Peng et al., “Nocturnal nutritional supplementation improves total body protein status of patients with liver cirrhosis: a randomized 12-month trial,” Hepatology, vol. 48, no. 2, pp. 557–566, 2008. View at: Publisher Site | Google Scholar
  31. Y. Chen, X. Wang, J. Wang, Z. Yan, and J. Luo, “Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies,” European Journal of Cancer, vol. 48, no. 14, pp. 2137–2145, 2012. View at: Publisher Site | Google Scholar
  32. S. Naveau, V. Giraud, E. Borotto, A. Aubert, F. Capron, and J.-C. Chaput, “Excess weight risk factor for alcoholic liver disease,” Hepatology, vol. 25, no. 1, pp. 108–111, 1997. View at: Google Scholar
  33. R. K. Dhiman, R. Kurmi, K. K. Thumburu et al., “Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver,” Digestive Diseases and Sciences, vol. 55, no. 8, pp. 2381–2390, 2010. View at: Publisher Site | Google Scholar
  34. S. Prasad, R. K. Dhiman, A. Duseja, Y. K. Chawla, A. Sharma, and R. Agarwal, “Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy,” Hepatology, vol. 45, no. 3, pp. 549–559, 2007. View at: Publisher Site | Google Scholar
  35. J. S. Bajaj, J. B. Wade, D. P. Gibson et al., “The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers,” American Journal of Gastroenterology, vol. 106, no. 9, pp. 1646–1653, 2011. View at: Publisher Site | Google Scholar
  36. F. Moscucci, S. Nardelli, I. Pentassuglio et al., “Previous overt hepatic encephalopathy rather than minimal hepatic encephalopathy impairs health-related quality of life in cirrhotic patients,” Liver International, vol. 31, no. 10, pp. 1505–1510, 2011. View at: Publisher Site | Google Scholar
  37. E. Wunsch, B. Szymanik, M. Post, W. Marlicz, M. Mydłowska, and P. Milkiewicz, “Minimal hepatic encephalopathy does not impair health-related quality of life in patients with cirrhosis: a prospective study,” Liver International, vol. 31, no. 7, pp. 980–984, 2011. View at: Publisher Site | Google Scholar
  38. H.-H. Tan, G. H. Lee, K. T. J. Thia, H. S. Ng, W. C. Chow, and H. F. Lui, “Minimal hepatic encephalopathy runs a fluctuating course: results from a three-year prospective cohort follow-up study,” Singapore Medical Journal, vol. 50, no. 3, pp. 255–260, 2009. View at: Google Scholar
  39. H. Schomerus and W. Hamster, “Quality of life in cirrhotics with minimal hepatic encephalopathy,” Metabolic Brain Disease, vol. 16, no. 1-2, pp. 37–41, 2001. View at: Publisher Site | Google Scholar
  40. V. Arvaniti, G. D'Amico, G. Fede et al., “Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis,” Gastroenterology, vol. 139, no. 4, pp. 1246.e5–1256.e5, 2010. View at: Publisher Site | Google Scholar
  41. J. S. Bajaj, J. G. O'Leary, F. Wong et al., “Bacterial infections in end-stage liver disease: current challenges and future directions,” Gut, vol. 61, pp. 1219–1225, 2012. View at: Google Scholar
  42. A. Tripodi and P. M. Mannucci, “The coagulopathy of chronic liver disease,” The New England Journal of Medicine, vol. 365, no. 2, pp. 147–156, 2011. View at: Publisher Site | Google Scholar

Copyright © 2013 Maja Thiele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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