Table of Contents
Hepatitis Research and Treatment
Volume 2013, Article ID 910519, 7 pages
http://dx.doi.org/10.1155/2013/910519
Clinical Study

Measuring the Response of Extrahepatic Symptoms and Quality of Life to Antiviral Treatment in Patients with Hepatitis C

1Brighton and Sussex Medical School, Brighton BN1 9PX, UK
2Medicine, Royal Sussex County Hospital, Brighton BN2 5BE, UK

Received 14 June 2013; Revised 17 September 2013; Accepted 18 September 2013

Academic Editor: Alessandro Antonelli

Copyright © 2013 David Isaacs et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. C. Teixeira, F. Ribeiro Mde, L. C. Gayotto, A. Chamone Dde, and E. Strauss, “Worse quality of life in volunteer blood donors with hepatitis C,” Transfusion, vol. 46, no. 2, pp. 278–283, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Hollander, G. R. Foster, and O. Weiland, “Health-related quality of life before, during and after combination therapy with interferon and ribavirin in unselected Swedish patients with chronic hepatitis C,” Scandinavian Journal of Gastroenterology, vol. 41, no. 5, pp. 577–585, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. B. M. Spiegel, Z. M. Younossi, R. D. Hays, D. Revicki, S. Robbins, and F. Kanwal, “Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment,” Hepatology, vol. 41, no. 4, pp. 790–800, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Weissenborn, A. B. Tryc, M. Heeren et al., “Hepatitis C virus infection and the brain,” Metabolic Brain Disease, vol. 24, no. 1, pp. 197–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. J. Rodger, D. Jolley, S. C. Thompson, A. Lanigan, and N. Crofts, “The impact of diagnosis of hepatitis C virus on quality of life,” Hepatology, vol. 30, no. 5, pp. 1299–1301, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Wright, R. Grieve, J. Roberts, J. Main, and H. C. Thomas, “Health benefits of antiviral therapy for mild chronic hepatitis C: randomised controlled trial and economic evaluation,” Health Technology Assessment, vol. 10, no. 21, pp. 1–113, 2006. View at Google Scholar · View at Scopus
  7. M. P. Neary, S. Cort, M. S. Bayliss, and J. E. Ware Jr., “Sustained virologic response is associated with improved health-related quality of life in relapsed chronic hepatitis C patients,” Seminars in Liver Disease, vol. 19, supplement 1, pp. 77–85, 1999. View at Google Scholar · View at Scopus
  8. J. E. Ware Jr., M. S. Bayliss, M. Mannocchia, and G. L. Davis, “Health-related quality of life in chronic hepatitis C: impact of disease and treatment response,” Hepatology, vol. 30, no. 2, pp. 550–555, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. J. G. McHutchison, J. E. Ware Jr., M. S. Bayliss et al., “The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity,” Journal of Hepatology, vol. 34, no. 1, pp. 140–147, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Wright, D. Forton, J. Main et al., “Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial,” Journal of Viral Hepatitis, vol. 12, no. 1, pp. 58–66, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. H. H. Thein, P. Maruff, M. D. Krahn et al., “Improved cognitive function as a consequence of hepatitis C virus treatment,” HIV Medicine, vol. 8, no. 8, pp. 520–528, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Cacoub, T. Poynard, P. Ghillani et al., “Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment virus CMULTIVIRC Group. Multidepartment virus C,” Arthritis and Rheumatism, vol. 42, no. 10, pp. 2204–2212, 1999. View at Google Scholar
  13. C. Lormeau, G. Falgarone, D. Roulot, and M.-C. Boissier, “Rheumatologic manifestations of chronic hepatitis C infection,” Joint Bone Spine, vol. 73, no. 6, pp. 633–638, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Sène, N. Limal, and P. Cacoub, “Hepatitis C virus-associated extrahepatic manifestations: a review,” Metabolic Brain Disease, vol. 19, no. 3-4, pp. 357–381, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. A. L. Zignego, D. Macchia, M. Monti et al., “Infection of peripheral mononuclear blood cells by hepatitis C virus,” Journal of Hepatology, vol. 15, no. 3, pp. 382–386, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Pileri, Y. Uematsu, S. Campagnoli et al., “Binding of hepatitis C virus to CD81,” Science, vol. 282, no. 5390, pp. 938–941, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Ferri, A. Antonelli, M. T. Mascia et al., “HCV-related autoimmune and neoplastic disorders: the HCV syndrome,” Digestive and Liver Disease, vol. 39, supplement 1, pp. S13–S21, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. F. B. Bianchi, P. Muratori, A. Granito, G. Pappas, S. Ferri, and L. Muratori, “Hepatitis C and autoreactivity,” Digestive and Liver Disease, vol. 39, supplement 1, pp. S22–S24, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. K. I. Penny, A. M. Purves, B. H. Smith, W. A. Chambers, and W. C. Smith, “Relationship between the chronic pain grade and measures of physical, social and psychological well-being,” Pain, vol. 79, no. 2-3, pp. 275–279, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Bartolomé, E. Rodríguez-Iñigo, A. Erice, S. Vidal, I. Castillo, and V. Carreño, “Hepatitis C virus does not infect muscle, the intervertebral disk, or the meniscus in patients with chronic hepatitis C,” Journal of Medical Virology, vol. 79, pp. 1818–1820, 2007. View at Google Scholar
  21. C. Palazzi, E. D'Amico, S. D'Angelo, A. Nucera, A. Petricca, and I. Olivieri, “Hepatitis C virus infection in Italian patients with fibromyalgia,” Clinical Rheumatology, vol. 27, no. 1, pp. 101–103, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Narváez, J. M. Nolla, and J. Valverde-García, “Lack of association of fibromyalgia with hepatitis C virus infection,” The Journal of Rheumatology, vol. 32, pp. 1118–1121, 2005. View at Google Scholar
  23. P. Cacoub, V. Ratziu, R. P. Myers et al., “Impact of treatment on extra hepatic manifestations in patients with chronic hepatitis C,” Journal of Hepatology, vol. 36, no. 6, pp. 812–818, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Saadoun, A. Delluc, J. C. Piette, and P. Cacoub, “Treatment of hepatitis C-associated mixed cryoglobulinemia vasculitis,” Current Opinion in Rheumatology, vol. 20, no. 1, pp. 23–28, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. S. Bayliss, B. Gandek, K. M. Bungay, D. Sugano, M.-A. Hsu, and J. E. Ware Jr., “A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C,” Quality of Life Research, vol. 7, no. 1, pp. 39–55, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Griffiths, E. Romeri, A. Brock, and O. Morgan, “Geographical variations in deaths related to drug misuse in England and Wales, 1993–2006,” Health Statistics Quarterly, no. 39, pp. 14–21, 2008. View at Google Scholar · View at Scopus
  27. R. J. Fontana, K. B. Hussain, S. M. Schwartz, C. A. Moyer, G. L. Su, and A. S. Lok, “Emotional distress in chronic hepatitis C patients not receiving antiviral therapy,” Journal of Hepatology, vol. 36, no. 3, pp. 401–407, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Golden, R. M. Conroy, A. M. O'Dwyer, D. Golden, and J.-B. Hardouin, “Illness-related stigma, mood and adjustment to illness in persons with hepatitis C,” Social Science and Medicine, vol. 63, no. 12, pp. 3188–3198, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. G. Carta, M. C. Hardoy, A. Garofalo et al., “Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy,” Clinical Practice and Epidemiology in Mental Health, vol. 3, article 22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. D. M. Forton, H. C. Thomas, C. A. Murphy et al., “Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease,” Hepatology, vol. 35, no. 2, pp. 433–439, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Rivera, A. de Diego, M. Trinchet, and A. García Monforte, “Fibromyalgia-associated hepatitis C virus infection,” British Journal of Rheumatology, vol. 36, no. 9, pp. 981–985, 1997. View at Google Scholar · View at Scopus
  32. C. Mazzaro, G. Pozzato, F. Zorat et al., “Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia,” Digestive and Liver Disease, vol. 39, supplement 1, pp. S102–S106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Jorgensen, M.-C. Legouffe, P. Perney et al., “Sicca syndrome associated with hepatitis C virus infection,” Arthritis and Rheumatism, vol. 39, no. 7, pp. 1166–1171, 1996. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Ramos-Casals, S. De Vita, and A. G. Tzioufas, “Hepatitis C virus, Sjögren's syndrome and B-cell lymphoma: linking infection, autoimmunity and cancer,” Autoimmunity Reviews, vol. 4, no. 1, pp. 8–15, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Sterling and S. Bralow, “Extrahepatic manifestations of hepatitis C virus,” Current Gastroenterology Reports, vol. 8, no. 1, pp. 53–59, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. K. V. Knutsen, M. Brekke, S. Gjelstad, and P. Lagerløv, “Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway,” Scandinavian Journal of Primary Health Care, vol. 28, no. 3, pp. 166–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. J.-M. Durand, P. Cacoub, F. Lunel-Fabiani et al., “Ribavirin in hepatitis C related cryoglobulinemia,” Journal of Rheumatology, vol. 25, no. 6, pp. 1115–1117, 1998. View at Google Scholar · View at Scopus
  38. J. W. Levine, C. Gota, B. J. Fessler, L. H. Calabrese, and S. M. Cooper, “Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus,” Journal of Rheumatology, vol. 32, no. 6, pp. 1164–1167, 2005. View at Google Scholar · View at Scopus