Table of Contents
Hepatitis Research and Treatment
Volume 2013 (2013), Article ID 917261, 6 pages
http://dx.doi.org/10.1155/2013/917261
Clinical Study

Involvement of Differential Relationship between HCV Replication and Hepatic PRR Signaling Gene Expression in Responsiveness to IFN-Based Therapy

1Department of Gastroenterology, Osaka National Hospital, Hoenzaka 2-1-14, Chuo-ku, Osaka 540-0006, Japan
2BML, Inc., Kawagoe 350-1101, Japan
3Department of Gastroenterology, Minamiwakayama National Hospital, Tanabe 646-8558, Japan

Received 12 March 2013; Revised 14 November 2013; Accepted 2 December 2013

Academic Editor: Man-Fung Yuen

Copyright © 2013 Nobukazu Yuki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Gale Jr. and E. M. Foy, “Evasion of intracellular host defence by hepatitis C virus,” Nature, vol. 436, no. 7053, pp. 939–945, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. E. C. Freundt and M. J. Lenardo, “Interfering with interferons: hepatitis C virus counters innate immunity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 49, pp. 17539–17540, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Meylan, J. Curran, K. Hofmann et al., “Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus,” Nature, vol. 437, no. 7062, pp. 1167–1172, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Li, E. Foy, J. C. Ferreon et al., “Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 8, pp. 2992–2997, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. X. D. Li, L. Sun, R. B. Seth, G. Pineda, and Z. J. Chen, “Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 49, pp. 17717–17722, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. G. Katze, Y. He, and M. Gale Jr., “Viruses and interferon: a fight for supremacy,” Nature Reviews Immunology, vol. 2, no. 9, pp. 675–687, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Bellecave, M. Sarasin-Filipowicz, O. Donzé et al., “Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system,” Hepatology, vol. 51, no. 4, pp. 1127–1136, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Jouan, L. Chatel-Chaix, P. Melanon et al., “Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients,” Journal of Hepatology, vol. 56, no. 1, pp. 70–77, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Yuki, S. Matsumoto, M. Kato, and T. Yamaguchi, “Hepatic Toll-like receptor 3 expression in chronic hepatitis C genotype 1 correlates with treatment response to peginterferon plus ribavirin,” Journal of Viral Hepatitis, vol. 17, no. 2, pp. 130–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Yuki, S. Matsumoto, K. Tadokoro, K. Mochizuki, M. Kato, and T. Yamaguchi, “Significance of liver negative-strand HCV RNA quantitation in chronic hepatitis C,” Journal of Hepatology, vol. 44, no. 2, pp. 302–309, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. R. G. Knodell, K. G. Ishak, W. C. Black et al., “Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis,” Hepatology, vol. 1, no. 5, pp. 431–435, 1981. View at Google Scholar · View at Scopus