Research Article
Interleukin-16 Gene Polymorphisms Are Considerable Host Genetic Factors for Patients’ Susceptibility to Chronic Hepatitis B Infection
Table 2
Allele and genotype frequency of three SNPs among chronic HBV patients versus healthy control subjects.
| | SNP | Variable | Healthy control ( = 394) (%) | HBV patient ( = 245) (%) | Adjusted OR (95% CI), |
| | rs4072111 | Genotypes | | | | | CC | 316 (80.2) | 181 (73.9) | 1.00 (reference) | | CT | 74 (18.8) | 58 (23.7) | 1.391 (0.937–2.066), 0.102 | | TT | 4 (1.0) | 6 (2.4) | 2.929 (0.787–10.894), 0.109 | | Alleles | | | | | C | 706 (89.6) | 420 (85.7) | 1.00 (reference) | | T | 82 (10.4) | 70 (14.3) | 1.471 (1.039–2.081), 0.029 |
| | rs11556218 | Genotypes | | | | | TT | 124 (31.5) | 43 (17.6) | 1.00 (reference) | | TG | 215 (54.6) | 147 (60) | 2.028 (1.344–3.061), 0.001 | | GG | 55 (14) | 55 (22.4) | 2.894 (1.722–4.864), 0.000 | | Alleles | | | | | T | 463 (58.8) | 233 (47.6) | 1.00 (reference) | | G | 325 (41.2) | 257 (52.4) | 1.574 (1.250–1.982), 0.000 |
| | rs4778889 | Genotypes | | | | | TT | 264 (67) | 156 (63.7) | 1.00 (reference) | | TC | 111 (28.2) | 84 (34.3) | 1.303 (0.916–1.853), 0.140 | | CC | 19 (4.8) | 5 (2) | 0.439 (0.159–1.216), 0.113 | | Alleles | | | | | T | 639 (81.1) | 396 (80.8) | 1.00 (reference) | | C | 149 (18.9) | 94 (19.2) | 1.027 (0.767–1.375), 0.860 |
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Adjusted for confounder variables: age and gender.
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