Research Article
Interleukin-16 Gene Polymorphisms Are Considerable Host Genetic Factors for Patients’ Susceptibility to Chronic Hepatitis B Infection
Table 3
Allele and genotype frequency of three SNPs among chronic HBV patients versus HBV clearance subjects.
| | SNP | Variable | HBV clearance ( = 105) (%) | HBV patient ( = 245) (%) | Adjusted OR (95% CI), |
| | rs4072111 | Genotypes | | | | | CC | 86 (81.9) | 181 (73.9) | 1.00 (reference) | | CT | 17 (16.2) | 58 (23.7) | 0.577 (0.307–1.082), 0.086 | | TT | 2 (1.9) | 6 (2.4) | 0.814 (0.142–4.672), 0.817 | | Alleles | | | | | C | 189 (89.6) | 420 (85.7) | 1.00 (reference) | | T | 21 (10.4) | 70 (14.3) | 0.651 (0.378–1.121), 0.122 |
| | rs11556218 | Genotypes | | | | | TT | 16 (15.2) | 43 (17.6) | 1.00 (reference) | | TG | 63 (60) | 147 (60) | 1.118 (0.567–2.203), 0.748 | | GG | 26 (24.8) | 55 (22.4) | 1.298 (0.594–2.836), 0.513 | | Alleles | | | | | T | 95 (45.2) | 233 (47.6) | 1.00 (reference) | | G | 115 (54.8) | 257 (52.4) | 1.109 (0.788–1.561), 0.509 |
| | rs4778889 | Genotypes | | | | | TT | 68 (64.8) | 156 (63.7) | 1.00 (reference) | | TC | 29 (27.6) | 84 (34.3) | 0.785 (0.459–1.342), 0.376 | | CC | 8 (7.6) | 5 (2) | 3.723 (1.100–12.602), 0.035 | | Alleles | | | | | T | 165 (78.6) | 396 (80.8) | 1.00 (reference) | | C | 45 (21.4) | 94 (19.2) | 1.144 (0.751–1.744), 0.531 |
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Adjusted for confounder variables: age and gender.
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