|
| Author, year, country | | Association | Subjects | Comment |
|
|
Vassalle et al., 2004 [23], Italy | Case control | Positive | 491 with CAD (6.3% HCV seropositive)/195 controls (2% HCV seropositive) | First study that suggested HCV seropositivity as one of the risk factors affecting the onset and development of CAD |
|
| Butt et al., 2009 [24], USA | Prospective observational cohort study, 5 yr follow-up | Positive | 82,083 HCV infected/89,582 HCV uninfected subjects | HCV infection is associated with a higher risk of CAD after adjustment for traditional risk factors |
|
| Alyan et al., 2008 [25], Turkey | Case control | Positive | 139 HCV seropositive/225 HCV seronegative patients | HCV infection is an independent predictor for increased coronary atherosclerosis (higher Reardon severity score) |
|
| Adinolfi et al., 2013 [26], Italy | Retrospective cohort study | Positive | 820/78 HCV infected | A secondary analysis showed that HCV patients had higher prevalence of past ischemic heart disease |
|
| Oliveira et al., 2013 [27], Brazil | Cross-sectional comparative study | Positive | 62 HCV infected/11 controls | HCV infection was related to higher FRS as well as to higher pro-anti-inflammatory cytokine profile |
|
| Enger et al., 2014 [28], USA | Retrospective matched cohort study | Positive | 22,733 HCV infected/68,198 comparators | Arterial events, especially unstable angina and transient ischemic attack, were more frequently seen in HCV patients |
|
| Satapathy et al., 2013 [29], USA | Retrospective, case control study | Positive | 63 HCV infected patients/63 controls | The prevalence and severity of CAD were higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients |
|
| Pothineni et al., 2014 [30], USA | Retrospective cohort study | Positive | 8,251 HCV antibody positive/1,434 HCV RNA positive/14,799 HCV negative patients | Increased incidence of CHD events in patients with HCV seropositivity; the incidence is much higher in patients with detectable HCV RNA compared with patients with remote infection who are only antibody positive |
|
| Wong et al., 2014 [31], USA | Systematic review | Unclear association | | Systematic review |
|
| Forde et al., 2012 [32], UK | Retrospective, population cohort, 3.9 yr follow-up | Negative | 4809 HCV seropositive/71 668 seronegative | No correlation between HCV and MI but short period of follow-up of the subjects and moreover chronic HCV infection was poorly proved |
|
| Arcari et al., 2006 [33], USA | Case control | Negative | 292 case subjects/290 controls, overall 52 HCV positive | No association was found between HCV positivity and acute myocardial infarction |
|
| Momiyama et al., 2005 [34], Japan | Case control | Negative | 524 with CAD (3.4% HCV infected)/106 controls | |
|
