Table of Contents
Hepatitis Research and Treatment
Volume 2017, Article ID 2131627, 6 pages
Research Article

Assessment of Immunization to Hepatitis B Vaccine among Children under Five Years in Rural Areas of Taiz, Yemen

1Microbiology and Immunology Departments, Military Hospital, Sana’a, Yemen
2Pediatrics Department, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen
3Pediatrics Department, Al-Sabeen Maternity and Child Hospital, Sana’a, Yemen
4Virology and Serology Department, Military Hospital, Sana’a, Yemen
5Department of Biological Sciences, Ohio University Zanesville, Zanesville, OH, USA
6National Center for Research, Khartoum, Sudan

Correspondence should be addressed to Fuad A. A. Alssamei; moc.oohay@yimasdauf

Received 18 November 2016; Accepted 22 January 2017; Published 6 March 2017

Academic Editor: Man-Fung Yuen

Copyright © 2017 Fuad A. A. Alssamei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Hepatitis B virus (HBV) infection poses a major health problem worldwide. approximately 1 million deaths annually due to cirrhosis and hepatocellular carcinoma. Objectives. This study was conducted to determine the coverage rate of HBV vaccine and assess the vaccine protective response among children under five years old in rural areas of Yemen. Methods. A cross-sectional study was conducted from January to December 2015 in four districts of countryside Yemen. The target population was children aged from 6 to 59 months. 227 children were enrolled in the study. Questionnaire was used to collect of data. Serum samples were tested for anti-HBs antibodies by enzyme linked immunosorbent assay (ELISA). Anti-HBs level ≥ 10 IU/L was considered a protective response to the vaccine. Results. The coverage rate of HBV vaccine among children was 87.3%. A total of 143 (72.2%) children responded to the vaccine with anti-HBs level ≥ 10 IU/L, while 55 (27.8%) of the children had nonprotective anti-HBs levels of <10 IU/L (P = 0.003). Conclusion. This study revealed a good coverage rate of HBV vaccine in rural areas but the protective rate against HBV infection was moderate. A considerable proportion of vaccinated children should be considered for either revaccination or booster doses.