Table of Contents
HPB Surgery
Volume 1, Issue 1, Pages 15-20

Common Bile-Duct Mucosa in Choledochoduodenostomy Patients — Histological and Histochemical Study

1Department of Surgery, University of Thessaloniki, Greece
2Department of Pathology, University of Thessaloniki, Greece
3Department of Surgery, University of Thessaloniki, Thessaloniki GR-54006, Greece

Accepted 17 March 1988

Copyright © 1988 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe the histological and histochemical changes of the common bile-duct mucosa in specimens obtained by means of peroral cholangioscopy, 1–12 years after choledochoduodenal anastomosis. Our findings — hyperplasia of the superficial epithelium, metaplastic goblet cells containing predominantly acid sialomucins, and pyloric-like gland formation containing neutral mucins — express a morphological and functional differentiation of the common bile-duct mucosa that probably facilitates its survival in a different environment. We consider that these adaptive changes may explain the uneventful long-term postoperative period of choledochoduodenostomized patients.