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HPB Surgery
Volume 1, Issue 4, Pages 309-317
http://dx.doi.org/10.1155/1989/84039

CT-Guided Pancreatic Percutaneous Fine-Needle Biopsy in Differential Diagnosis between Pancreatic Cancer and Chronic Pancreatitis

1Cattedre di Patologia Speciale Chirurgica, Istituto Scientifico H.S. Raffaele, Università di Milano, Italy
2Cattedre di Radiologia, Istituto Scientifico H.S. Raffaele, Università di Milano, Italy
3Cattedre di Anatomia Patologica, Istituto Scientifico H.S. Raffaele, Università di Milano, Italy
4Cattedre di Statistica Medica, Istituto Scientifico H.S. Raffaele, Università di Milano, Italy
5Cattedra Patologia Chirurgica, Istituto Scientifico H.S. Raffael, Universita' di Milano, Via Olgettina 60, Milano 20132, Italy

Received 29 June 1988

Copyright © 1989 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Differential diagnosis between pancreatic cancer and chronic pancreatitis is still difficult to establish. In 63 patients with suspected pancreatic neoplasm we performed: serum CA 19-9 assessment, abdominal ultrasound, CT scan and CT-guided pancreatic percutaneous fine-needle biopsy. The conclusive diagnosis was pancreatic cancer in 40 patients and chronic pancreatitis in 23 patients. With regard to the differential diagnosis, sensitivity and specificity were respectively 80% and 78% for serum CA 19-9, 75% and 65% for abdominal US, 85% and 70% for CT scan, 00% and 87% for percutaneous fine-needle biopsy. We conclude that CT-guided percutaneous fine-needle biopsy is the most reliable method for differential diagnosis between pancreatic cancer and chronic pancreatitis.