Table of Contents
HPB Surgery
Volume 2, Issue 2, Pages 135-144
http://dx.doi.org/10.1155/1990/12854

Cell Kinetics of Hepatic Metastases as a Prognostic Marker in Patients With Advanced Colorectal Carcinoma

1Surgical Oncology A, lstituto Nazionale per lo Studio e la Cura dei Tumori Via Venezian, Milan 1-20133, Italy
2Nuclear Medicine Service, lstituto Nazionale per lo Studio e la Cura dei Tumori Via Venezian, Milan 1-20133, Italy
3Istituto Nazionale Tumori, Via Venezian 1, Milan 20133, Italy

Received 21 March 1989

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cell kinetics was determined, as 3H-thymidine labeling index (LI), in hepatic lesions from 36 patients with primary colorectal carcinoma; LI values ranged from 0.9% to 23.5% and were normally distributed. Cell kinetics was not related to sex or age of the patient, or to liver function. For clinical studies the median LI value of 10% was used to separate slowly and rapidly proliferating lesions. Univariate analysis showed that patients radically resected and with a low LI tumor have a longer disease-free interval and a better probability of 12-month survival than those non-radically resected and with a high LI tumor. When treatment and cell kinetics were taken into consideration, the probability of 12-month survival was 100% for patients with slowly proliferating and radically resected hepatic metastases. Patients with rapidly proliferating tumors, regardless of type of treatment, had the worst prognosis.