Table of Contents
HPB Surgery
Volume 5, Issue 4, Pages 221-227

The Management of Persistent or Recurrent Variceal Bleeding After Injection Sclerotherapy by Somatostatin

University Department of Surgery, 5th Floor, U.C.D., Royal Liverpool University Hospital, Prescot Street, Liverpool L69 3BX, UK

Received 25 September 1991; Accepted 15 November 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sixteen patients with persistent (n = 11) or recurrent (n = 5) variceal bleeding after injection sclerotherapy and balloon tamponade were treated with an intravenous infusion of somatostatin 250μg/ h. Somatostatin infusion successfully controlled the bleeding in 15 of the 16 patients but one rebled after 72 h of treatment. In one patient with poor liver function (Child’s C) bleeding was not controlled by somatostatin, further injection sclerotherapy or balloon tamponade of the oesophagus. The results of this study, although uncontrolled and with a small number of patients, suggest that somatostatin is a very effective treatment for the control of post-injection sclerotherapy variceal bleeding.