Table of Contents
HPB Surgery
Volume 8, Issue 4, Pages 241-244

Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

1Currently Consultant, Department of Surgery, Wrexham Maelor Hospital Trust, Clwyd, Wrexham LL13 7, TX, USA
2Efamol Research Institute, Kentville B4N 4H8, Nova Scotia, Canada
3Hepato-Pancreatico-Biliary Surgery Unit, University of Wales College of Medicine, Heath Park, Wales, Cardiff CF4 4XN, UK

Received 28 October 1993

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Changes in fatty acid patterns may explain many of the observed abnormalities found in obstructive jaundice. This study looked at fatty acids in plasma cholesterol esters, in a group of patients with obstructive jaundice and a matched group of controls. Significant abnormalities were demonstrated, most importantly a fall in essential fatty acids, in the jaundiced group. Overall the saturation of this fraction, as assessed by double bond index, rose. The essential fatty acids are important as factors in membrane function and as precursors of eicosanoids. The abnormalities found in this study provide further evidence of the significance of EFA in patients with obstructive jaundice.