Abstract
Nesidioblastosis is an exceedingly rare occurrence in the adult and, when it appears, it is usually part of a MEA1 syndrome.We present a case of nesidioblastosis in a young woman, with no concurrent endocrine pathology, while we discuss in detail the diagnostic and therapeutic problems posed by this condition.The selected treatment was sub-total pancreatectomy (70–80%) and the histopathologic and immunohistochemical tests of the surgical specimen showed: “Diffuse Nesidioblastosis”.The histopathologic and immuno-histochemical features of the resected pancreas are analysed in detail.