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HPB Surgery
Volume 10 (1997), Issue 4, Pages 201-209

Nesidioblastosis in the Adult Surgical Management

St. Martha's Hospital - General Surgery and Histopathology Wards, Rua de Santa Marta, Lisboa 1100, Portugal

Received 21 July 1995

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nesidioblastosis is an exceedingly rare occurrence in the adult and, when it appears, it is usually part of a MEA1 syndrome.

We present a case of nesidioblastosis in a young woman, with no concurrent endocrine pathology, while we discuss in detail the diagnostic and therapeutic problems posed by this condition.

The selected treatment was sub-total pancreatectomy (70–80%) and the histopathologic and immunohistochemical tests of the surgical specimen showed: “Diffuse Nesidioblastosis”.

The histopathologic and immuno-histochemical features of the resected pancreas are analysed in detail.