Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

Table 4

Results of meta-analysis.

Studies included	Number of studies included	Participants	Odds ratio [95% confidence intervals]	Statistical significance	Heterogeneity (Higgins' I^2)
One-year survival
All	4	425	0.08 [0.01, 0.47]^†	Significant	75.1%
Three-year survival
All	9	938	0.15 [0.08, 0.26]	Significant	7.9%
Microscopic node involvement	3	232	0.24 [0.11, 0.55]	Significant	0%
Routine lymphadenectomy	7	832	0.13 [0.06, 0.28]^†	Significant	27.3%
Hepatoduodenal ligament only	3	430	0.24 [0.11, 0.55]	Significant	0%
Hepatic pedicle	4	402	0.20 [0.10, 0.39]	Significant	0%
Adjuvant chemotherapy	2	177	0.10 [0.01, 1.03]^†	Not significant	63.5%
Published before 2000	7	622	0.09 [0.04, 0.18]	Significant	1.8%
Published after 2000	2	316	0.17 [0.05, 0.57]^†	Significant	46.1%
Five-year survival
All	7	904	0.10 [0.04, 0.27]	Significant	0%
Microscopic node involvement	2	220	0.14 [0.03, 0.72]	Significant	0%
Routine lymphadenectomy	6	810	0.09 [0.03, 0.24]	Significant	0%
Hepatoduodenal ligament only	3	430	0.09 [0.02, 0.38]	Significant	0%
Hepatic pedicle	3	380	0.08 [0.02, 0.34]	Significant	0%
Adjuvant chemotherapy	1	155	0.05 [0.00, 0.81]	Significant	Not applicable
Published before 2000	5	588	0.09 [0.03, 0.29]	Significant	0%
Published after 2000	2	316	0.07 [0.01, 0.38]	Significant	0%
One-year disease-free survival
All	1	94	0.24 [0.05, 1.15]	Not significant	Not applicable
Three-year disease-free survival
All	1	94	0.10 [0.01, 1.78]	Not significant	Not applicable
Five-year disease-free survival
All	1	94	0.15 [0.01, 2.81]	Not significant	Not applicable

^†Random-effects model as there was statistical heterogeneity.