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HPB Surgery
Volume 2009 (2009), Article ID 878490, 5 pages
Research Article

Serum Profiles of C-Reactive Protein, Interleukin-8, and Tumor Necrosis Factor- 𝛼 in Patients with Acute Pancreatitis

1Department of Surgery, “Asklepieio Voulas” General Hospital, 16673 Athens, Greece
2Department of Microbiology, “Tzaneio” General Hospital, 18536 Piraeus, Greece

Received 10 May 2009; Revised 28 July 2009; Accepted 16 November 2009

Academic Editor: Jakob Izbicki

Copyright © 2009 Michael K. Digalakis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background-Aims. Early prediction of the severity of acute pancreatitis would lead to prompt intensive treatment resulting in improvement of the outcome. The present study investigated the use of C-reactive protein (CRP), interleukin IL-8 and tumor necrosis factor- 𝛼 (TNF- 𝛼 ) as prognosticators of the severity of the disease. Methods. Twenty-six patients with acute pancreatitis were studied. Patients with APACHE II score of 9 or more formed the severe group, while the mild group consisted of patients with APACHE II score of less than 9. Serum samples for measurement of CRP, IL-8 and TNF- 𝛼 were collected on the day of admission and additionally on the 2nd, 3rd and 7th days. Results. Significantly higher levels of IL-8 were found in patients with severe acute pancreatitis compared to those with mild disease especially at the 2nd and 3rd days ( 𝑃 = . 0 0 1 and 𝑃 = . 0 1 4 , resp.). No significant difference for CRP and TNF- 𝛼 was observed between the two groups. The optimal cut-offs for IL-8 in order to discriminate severe from mild disease at the 2nd and 3rd days were 25.4 pg/mL and 14.5 pg/mL, respectively. Conclusions. IL-8 in early phase of acute pancreatitis is superior marker compared to CRP and TNF- 𝛼 for distinguishing patients with severe disease.