Table of Contents
HPB Surgery
Volume 2010, Article ID 906496, 7 pages
Clinical Study

Eosinophilic Cholangitis and Cholangiopathy: A Sheep in Wolves Clothing

1School of Medicine, St. George’s University, Grenada
2Department of Surgery, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ 07039, USA
3Department of Pathology, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ 07039, USA
4Department of Surgery, Saint Barnabas Medical Center, University of Medicine & Dentistry of New Jersey, 150 Bergen Street, Newark, NJ 07103, USA

Received 1 July 2010; Accepted 7 October 2010

Academic Editor: J. R. Izbicki

Copyright © 2010 Catherine Nashed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Eosinophilic cholangitis (EC) is a rare benign disorder of the biliary tract which can cause biliary obstruction. Similar to other disease processes involving the bile ducts, this disorder can pose a difficult diagnostic challenge as it can mimic cholangiocarcinoma. Methods. A systematic search of the scientific literature was carried out using PubMed to access all publications related to EC. Search keywords that were utilized included “eosinophilic cholangitis,” “etiology,” “treatment,” and “obstructive jaundice.” Results. Twenty-three cases of EC have been reported. Nineteen patients (82.6%) who presented with EC remain disease-free; 15 of these 19 patients (78.9%) with followup time remain disease-free at a mean of 9.7 months (range, 2–24 months). Conclusion. EC is a rare form of biliary obstruction which can masquerade as a malignancy. Unlike cholangiocarcinoma, EC occurs more commonly in younger patients and in men. Most patients will require surgical treatment.