The Dynamics of Glutathione Species and Ophthalmate Concentrations in Plasma from the VX2 Rabbit Model of Secondary Liver Tumors

Figure 6

Ophthalmate (OA) concentration in plasma from the VX2 rabbit model. The concentration of OA was measured in plasma from rabbits 2 weeks before tumor implantation and 2 weeks after tumor implantation. Levels of OA were similar in rabbits from the experimental group before tumor implantation when compared to the control (sham) group (𝑃>.05, one-sided independent 𝑡-test). In contrast, levels of OA were significantly higher in the experimental group when compared to the sham group after tumor implantation (𝑃<.01, one-sided independent 𝑡-test). Furthermore, levels of OA were significantly higher in the experimental group in the state of tumor growth when compared to the state of health (𝑃<.01, paired 𝑡-test).