Disturbances in the Glutathione/Ophthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma
Figure 2
Light microscopy of liver tissue from WHV-infected woodchucks. (a) Liver tissue is shown with areas of mild chronic hepatitis, steatosis, and mild portal fibrosis, characteristic of mild WHV infection (H&E, 100x), while other areas showed portal triad fibrosis with severe steatosis (b) progressing to bridging fibrosis (c). (d) A region of severe dysplasia versus HCC (H&E, 200x). (e) HCC with minimal steatosis containing mononuclear cells. (f) Liver tissue containing malignancy after complete tumor ablation (H&E, 100x) and a 2 mm margin around ablated area showing cell apoptosis (g), (TUNEL assay, 100x).
