Table of Contents Author Guidelines Submit a Manuscript
HPB Surgery
Volume 2011, Article ID 789323, 9 pages
http://dx.doi.org/10.1155/2011/789323
Research Article

Disturbances in the Glutathione/Ophthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma

1Department of Surgery, Case Western Reserve University School of Medicine and University Hospitals, Case Medical Center, Cleveland, OH 44106-7029, USA
2Department of Nutrition, Case Western Reserve University School of Medicine and University Hospitals, Case Medical Center, Cleveland, OH 44106-7029, USA
3Department of Pathology, Case Western Reserve University School of Medicine and University Hospitals, Case Medical Center, Cleveland, OH 44106-7029, USA
4Department of Radiology, Case Western Reserve University School of Medicine and University Hospitals, Case Medical Center, Cleveland, OH 44106-7029, USA
5Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University Hospitals, Case Medical Center, Lakeside 7510, PS 5047, Cleveland, OH 44106, USA

Received 15 May 2011; Revised 18 July 2011; Accepted 19 July 2011

Academic Editor: Vito R. Cicinnati

Copyright © 2011 Rafael Andres Ibarra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. B. El-Serag, “Hepatocellular carcinoma: recent trends in the United States,” Gastroenterology, vol. 127, no. 5, 1, pp. S27–S34, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Fuss and C. R. Thomas Jr., “Stereotactic body radiation therapy: an ablative treatment option for primary and secondary liver tumors,” Annals of Surgical Oncology, vol. 11, no. 2, pp. 130–138, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma,” Hepatology, vol. 42, no. 5, pp. 1208–1236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma: an update,” Hepatology, vol. 53, no. 3, pp. 1020–1022, 2011. View at Publisher · View at Google Scholar
  5. M. Sherman, “Screening for hepatocellular carcinoma,” Hepatology Research, vol. 37, supplement 2, pp. S152–S165, 2007. View at Publisher · View at Google Scholar
  6. P. Stefaniuk, J. Cianciara, and A. Wiercinska-Drapalo, “Present and future possibilities for early diagnosis of hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 16, no. 4, pp. 418–424, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Lusini, S. A. Tripodi, R. Rossi et al., “Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma,” International Journal of Cancer, vol. 91, no. 1, pp. 55–59, 2001. View at Google Scholar · View at Scopus
  8. J. Navarro, E. Obrador, J. Carretero et al., “Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo,” Free Radical Biology and Medicine, vol. 26, no. 3-4, pp. 410–415, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Jaruga, T. H. Zastawny, J. Skokowski, M. Dizdaroglu, and R. Olinski, “Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer,” FEBS Letters, vol. 341, no. 1, pp. 59–64, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Soga, R. Baran, M. Suematsu et al., “Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption,” Journal of Biological Chemistry, vol. 281, no. 24, pp. 16768–16776, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Abbas, R. S. Kombu, R. A. Ibarra, K. K. Goyal, H. Brunengraber, and J. R. Sanabria, “The dynamics of glutathione species and ophthalmate concentrations in plasma from the VX2 rabbit model of secondary liver tumors,” HPB Surgery, vol. 2011, Article ID 709052, 8 pages, 2011. View at Publisher · View at Google Scholar
  12. N. Salem, Y. Kuang, D. Corn et al., “[(Methyl)1-11C]-acetate metabolism in hepatocellular carcinoma,” Molecular Imaging and Biology, vol. 13, no. 1, pp. 140–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Wang, Y. Kuang, N. Salem, P. W. Anderson, and Z. Lee, “Cross-species hybridization of woodchuck hepatitis viral infection-induced woodchuck hepatocellular carcinoma using human, rat and mouse oligonucleotide microarrays,” Journal of Gastroenterology and Hepatology, vol. 24, no. 4, pp. 605–617, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Summers, J. M. Smolec, and R. Snyder, “A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks,” Proceedings of the National Academy of Sciences of the United States of America, vol. 75, no. 9, pp. 4533–4537, 1978. View at Google Scholar · View at Scopus
  15. J. L. Gerin, P. J. Cote, B. E. Korba, and B. C. Tennant, “Hepadnavirus-induced liver cancer in woodchucks,” Cancer Detection and Prevention, vol. 14, no. 2, pp. 227–229, 1989. View at Google Scholar · View at Scopus
  16. R. S. Kombu, G. F. Zhang, R. Abbas et al., “Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans,” American Journal of Physiology—Endocrinology and Metabolism, vol. 297, no. 1, pp. E260–E269, 2009. View at Publisher · View at Google Scholar
  17. N. Salem, Y. Kuang, F. Wang, G. T. Maclennan, and Z. Lee, “PET imaging of hepatocellular carcinoma with 2-deoxy-2[18F] fluoro-D-glucose, 6-deoxy-6[18F]fluoro-D-glucose, [1-11C]-acetate and [N-methyl-11C]-choline,” Quarterly Journal of Nuclear Medicine and Molecular Imaging, vol. 53, no. 2, pp. 144–156, 2009. View at Google Scholar · View at Scopus
  18. G. Mantovani, C. Madeddu, A. Maccio et al., “Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment,” Cancer Epidemiology, Biomarkers & Prevention, vol. 13, no. 10, pp. 1651–1659, 2004. View at Google Scholar · View at Scopus
  19. G. Mantovani, A. Maccio, C. Madeddu et al., “Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: correlation with stage and performance status,” International Journal of Cancer, vol. 98, no. 1, pp. 84–91, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Franco and J. A. Cidlowski, “Apoptosis and glutathione: beyond an antioxidant,” Cell Death & Differentiation, vol. 16, no. 10, pp. 1303–1314, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. M. Estrela, A. Ortega, and E. Obrador, “Glutathione in cancer biology and therapy,” Critical Reviews in Clinical Laboratory Sciences, vol. 43, no. 2, pp. 143–181, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. H. H. Wu and J. Momand, “Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation,” Journal of Biological Chemistry, vol. 273, no. 30, pp. 18898–18905, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. C. K. Sen and L. Packer, “Antioxidant and redox regulation of gene transcription,” FASEB Journal, vol. 10, no. 7, pp. 709–720, 1996. View at Google Scholar · View at Scopus
  24. J. Carretero, E. Obrador, M. J. Anasagasti, J. J. Martin, F. Vidal-Vanaclocha, and J. M. Estrela, “Growth-associated changes in glutathione content correlate with liver metastatic activity of B16 melanoma cells,” Clinical and Experimental Metastasis, vol. 17, no. 7, pp. 567–574, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. M. E. Anderson, R. J. Bridges, and A. Meister, “Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves γ-glutamyl transpeptidase,” Biochemical and Biophysical Research Communications, vol. 96, no. 2, pp. 848–853, 1980. View at Publisher · View at Google Scholar
  26. G. K. Balendiran, R. Dabur, and D. Fraser, “The role of glutathione in cancer,” Cell Biochemistry and Function, vol. 22, no. 6, pp. 343–352, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. E. M. Leslie, K. I. Ito, P. Upadhyaya, S. S. Hecht, R. G. Deeley, and S. P. Cole, “Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog,” Journal of Biological Chemistry, vol. 276, no. 30, pp. 27846–27854, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Ballatori and W. J. Dutczak, “Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes,” Journal of Biological Chemistry, vol. 269, no. 31, pp. 19731–19737, 1994. View at Google Scholar · View at Scopus
  29. C. Loguercio and A. Federico, “Oxidative stress in viral and alcoholic hepatitis,” Free Radical Biology & Medicine, vol. 34, no. 1, pp. 1–10, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Abel, K. M. De, D. J. van Schalkwyk, S. Swanevelder, M. C. Kew, and W. C. Gelderblom, “Altered lipid profile, oxidative status and hepatitis B virus interactions in human hepatocellular carcinoma,” Prostaglandins, Leukotrienes & Essential Fatty Acids, vol. 81, no. 5-6, pp. 391–399, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa, “In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases,” Journal of Hepatology, vol. 37, no. 1, pp. 56–62, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Kuang, N. Salem, H. Tian et al., “Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11C]choline: correlation with in Vivo metabolic studies,” Journal of Nuclear Medicine, vol. 52, no. 1, pp. 98–106, 2011. View at Publisher · View at Google Scholar
  33. K. T. Lee, S. M. Tsai, S. N. Wang et al., “Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma,” Clinical Biochemistry, vol. 40, no. 15, pp. 1157–1162, 2007. View at Publisher · View at Google Scholar · View at Scopus