Ischemic Preconditioning of Rat Livers from Non-Heart-Beating Donors Decreases Parenchymal Cell Killing and Increases Graft Survival after Transplantation
Decreased parenchymal and nonparenchymal cell killing by ischemic preconditioning after aortic clamping. Anesthesized rats were given a sham operation (control) or ischemic preconditioning by clamping of the hepatic artery and portal vein for 10 min followed by 5 min of blood reperfusion (IP). The aortas of the rats were then clamped for 60 min. After clamping, the livers were infused with cold UW solution containing trypan blue to label nonviable parenchymal (a) and nonparenchymal (b) cells. Data represent means S.E.M. from 5 rats per group per time point. * versus control by ANOVA.
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