C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation

Figure 4

Decreased mitochondrial depolarization after hemorrhage and resuscitation of JNK2-deficient mice. Multiphoton imaging of hepatic Rh123 fluorescence was performed at 4 h after sham operation to wildtype mice (a) and H/R of wildtype- (b) and JNK2-deficient (c) mice, as described in Section 2. The percentage of hepatocytes per HPF with depolarized mitochondria is plotted in (d). Bar is 10 μm. 𝑃<0.05 versus other groups; 𝑛=3 per group.

(a)

(b)

(c)

(d)