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HPB Surgery
Volume 2013 (2013), Article ID 689835, 6 pages
http://dx.doi.org/10.1155/2013/689835
Research Article

Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

1Research Division, Heart Institute (InCor), University of Sao Paulo School of Medicine, 05403-900 Sao Paulo, SP, Brazil
2Hospital do Cancer de Muriae, Fundacao Cristiano Varella, 36880-000 Muriae, MG, Brazil
3Liver Transplant Unit, University of Sao Paulo School of Medicine, Avenida Dr Arnaldo 455, Suite 3206, 01246-903 Sao Paulo, SP, Brazil

Received 24 April 2013; Accepted 9 July 2013

Academic Editor: James Shapiro

Copyright © 2013 Edson A. Ribeiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pentoxifylline (PTX) has been shown to have beneficial effects on microcirculatory blood flow. In this study we evaluate the potential hemodynamic and metabolic benefits of PTX during hepatic ischemia. We also test the hypothesis that portal PTX infusion can minimize the I/R injury when compared to systemic infusion. Methods. Twenty-four dogs (  kg) were subjected to portal triad occlusion (PTO) for 45 min. The animals were assigned to 3 groups: CT (control, PTO, ), PTX-syst (PTO + 25 mg/Kg of PTX IV, ), and PTX-pv (PTO + 25 mg/Kg of PTX in the portal vein, ). Animals were followed for 120 min. Systemic hemodynamics, gastrointestinal tract perfusion, oxygen-derived variables, and liver enzymes were evaluated throughout the experiment. Results. Animals treated with PTX presented significantly higher CO in the first hour after reperfusion, when compared to the CT (~3.7 vs. 2.1 L/min, ). Alanine aminotransferase (ALT) was similar in the PTX groups two hours after reperfusion but significantly higher in the CT (227 vs. ~64 U/L, ). Conclusion. PTX infusion was associated with hemodynamic benefits and was able to minimize liver injury during normothermic hepatic I/R. However, local PTX infusion was not associated with any significant advantage over systemic route.