Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

Table 2

Systemic (syst) and splanchnic (splanc) oxygen delivery, consumption and extraction (DO₂, VO₂, and O₂ ER, resp.) in CT (control, portal triad clamping, 𝑛=8), PTX-syst (portal triad clamping + 25 mg/Kg of PTX intravenous systemically, 𝑛=8), and PTX-pv (portal triad clamping + 25 mg/Kg of PTX in the portal vein, 𝑛=8) groups.

	Group	BL	P45	R15	R60	R120
DO2 syst mL/min	CT	483±76	449±58	367±40^a,b,c	254±29^a,b,c	211±61^a,b
	PTX-syst	454±39	496±62	580±76	479±62	381±56
	PTX-pv	411±89	530±43	707±109^a	578±83^a	416±63
VO2 syst mL/min	CT	10±3.1	12.8±7.8	4.7±0.8	6.9±0.5	7.5±2.1
	PTX-syst	8.5±2	8.5±2.1	8.1±0.6	7.7±1.2	8.8±1.8
	PTX-pv	6.8±0.3	7.7±1.6	10.5±2.9	6.5±1.1	8.4±1
O2 ERsyst%	CT	16.9±2.9	17.7±3.9	14.8±3.5	23.7±1.8^a,b	33.9±2.4^a,b,c
	PTX-syst	16.7±1.7	16.5±3.4	13.7±1.9	18±3.4	19.9±2.4
	PTX-pv	15.3±1.5	14.2±2.2	18.8±4.5	14±20	20.6±2.9^a
DO2 splanc mL/min	CT	103±28^c	—	85±55	71±48	54±39^a,c
	PTX-syst	95±5	—	150±20	93±12	69±7^a
	PTX-pv	80±16	—	156±31	137±11	111±20
VO2 splanc mL/min	CT	6.4±0.4	—	8.2±1.5	9.4±0.8	10±1.1
	PTX-syst	10±1.4	—	17.7±3.4	8.3±2.2	8.7±0.5
	PTX-pv	9±0.9	—	14.5±2.7	10.9±1.7	8.3±1.8
O2 ERsplanc%	CT	80±16^b	—	124±35	156±13^a,b,c	192±13^a,b,c
	PTX-syst	121±5	—	108±12	92±4	134±4
	PTX-pv	104±1.3	—	115±36	82±13	87±17

Legends: BL: baseline; P45: 45 min after Pringle’s maneuver; R15, R60, and R120: 15, 60, and 120 min after reperfusion. Data are shown as mean ± SEM. ^aIndicates 𝑃<0.05 versus BL; ^bindicates 𝑃<0.05 versus PTX-sys; ^cindicates 𝑃<0.05 versus PTX-pv.