Hepatocellular Carcinoma in the Pediatric Population: A Population Based Clinical Outcomes Study Involving 257 Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1973–2011)

Table 2

Tumor characteristics of 63,514 adults and 257 pediatric patients with hepatocellular carcinoma from the Surveillance, Epidemiology, and End Results (SEER) database, 1973–2011.

Variables	Overall	Pediatric patients	Adult patients	value
(%)	63,771	257 (0.4%)	63,514 (99.6)	—
Morphology, (%)
Pleomorphic	17 (<0.0%)	0 (0.0%)	17 (<0.0%)	0.63
Clear cell	339 (0.5%)	3 (1.2%)	336 (0.5%)	0.16
Spindle cell	36 (0.1%)	0 (0.0%)	36 (0.1%)	0.81
Scirrhous	66 (0.1%)	0 (0.0%)	66 (0.1%)	0.77
Fibrolamellar	274 (0.4%)	62 (24.1%)	212 (0.3%)	0.71
NOS	63,039 (98.9%)	192 (74.7%)	62,847 (98.9%)	0.09
Grade, (%)
Well differentiated	7,813 (35.1%)	34 (35.8%)	7,779 (35.1%)	0.02
Moderately diff.	8,467 (38.0%)	33 (34.7%)	8,434 (38.0%)	0.01
Poorly diff.	5,317 (23.9%)	22 (23.2%)	5,295 (23.9%)	0.01
Undifferentiated	672 (3.0%)	6 (6.3%)	666 (3.0%)	0.06
Stage, (%)
Localized	25,755 (47.9%)	68 (28.1%)	25,687 (48.0%)	<0.001
Regional	16,777 (31.2%)	94 (38.8%)	16,683 (31.2%)	<0.001
Distant	11,193 (20.8%)	80 (33.1%)	11,113 (20.8%)	<0.001
Tumor size, (%)
Microscopic	45 (0.1%)	0 (0.0%)	45 (0.1%)	0.01
Under 2 cm	3,071 (7.9%)	16 (9.9%)	3,055 (7.8%)	0.02
2 to 4 cm	11,720 (30.0%)	17 (10.5%)	11,703 (30.1%)	0.02
Over 4 cm	24,255 (62.0%)	129 (79.6%)	24,126 (62.0%)	0.02

cm = centimeters; diff. = differentiated; = number; NOS = not otherwise specified; SD = standard deviation; data presented for patients with available information only.