Table of Contents
HPB Surgery
Volume 2018, Article ID 6094936, 9 pages
https://doi.org/10.1155/2018/6094936
Research Article

Prevalence of Steatosis Hepatis in the Eurotransplant Region: Impact on Graft Acceptance Rates

1Department of Surgery, Campus Charité Mitte ∣ Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité – Universitätsmedizin Berlin 13353, Germany
2BIH Charité Clinician Scientist Program, Berlin Institute of Health (BIH), Berlin 10178, Germany
3Berlin Institute of Health and Department of Nephrology and Critical Care Medicine, Charité Universitätsmedizin, Berlin 13353, Germany

Correspondence should be addressed to Igor M. Sauer; ed.etirahc@reuas.rogi

Received 17 July 2018; Accepted 17 October 2018; Published 1 November 2018

Academic Editor: Shu-Sen Zheng

Copyright © 2018 Simon Moosburner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Due to the shortage of liver allografts and the rising prevalence of fatty liver disease in the general population, steatotic liver grafts are considered for transplantation. This condition is an important risk factor for the outcome after transplantation. We here analyze the characteristics of the donor pool offered to the Charité – Universitätsmedizin Berlin from 2010 to 2016 with respect to liver allograft nonacceptance and steatosis hepatis. Of the 2653 organs offered to our center, 19.9% (n=527) were accepted for transplantation, 58.8% (n=1561) were allocated to other centers, and 21.3% (n = 565) were eventually discarded from transplantation. In parallel to an increase of the incidence of steatosis hepatis in the donor pool from 20% in 2010 to 30% in 2016, the acceptance rates for steatotic organs increased in our center from 22.3% to 51.5% in 2016 (p < 0.001), with the majority (86.9%; p > 0.001) having less than 30% macrovesicular steatosis hepatis. However, by 2016, the number of canceled transplantations due to higher grades of steatosis hepatis had significantly increased from 14.7% (n = 15) to 63.6% (42; p < 0.001). The rising prevalence of steatosis hepatis in the donor pool has led to higher acceptance rates of steatotic allografts. Nonetheless, steatosis hepatis remains a predominant phenomenon in discarded organs necessitating future concepts such as organ reconditioning to increase graft utilization.