HPB Surgery

Ischemia/Reperfusion Injury in Liver Surgery and Transplantation


Publishing date
15 Jun 2012
Status
Published
Submission deadline
27 Jan 2012

Lead Editor

1Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

2Departments of Pharmaceutical & Biomedical Sciences and Biochemistry & Molecular Biology, Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, USA

3Department of Surgery, University Hospital of Zurich, Raemistrasse, 8091 Zürich, Switzerland


Ischemia/Reperfusion Injury in Liver Surgery and Transplantation

Description

Despite medical advances, there is unfortunately still no guarantee for adequate liver function after extended resection and transplantation. Impaired liver function is associated with high morbidity and mortality. While the underlying mechanisms are only partly understood, they seem to have similar pathophysiological pathways.

Ischemia/reperfusion injury (IRI) is one of the main contributors to decreased liver function after liver surgery. Posthepatectomy failure is reported in up to 60-90% of cases, despite the fact that the liver remnant's volume in itself should be sufficient to maintain adequate function. After liver transplantation (LT), IRI cannot be avoided and is one of the ultimate factors that limits liver function after LT. Taking into account the various definitions of primary dysfunction and primary nonfunction as well as the number of grafts with high risk of failure and other risk factors, poor graft function is reported in up to 88% of patients after LT. While techniques that do not require hepatic vascular control for liver resection (LR) have evolved, surgical manipulation of the tissue itself during LR, donor hepatectomy, and LT is inevitable.

Organ-specific parameters, such as preexisting damage (i.e., steatosis/steatohepatitis), and additional liver injury, such as surgical trauma, perfusion/preservation solutions, cold/warm ischemia time, and reperfusion, have been identified as contributing towards IRI.

Although some risk factors for mortality and morbidity after hepatic surgery including LT are defined, very little is known about the mechanisms of injury and the complex net-like interrelations. To date, no valid clinical concepts to preserve hepatic integrity and guarantee sufficient regeneration in the context of both LT and LR have evolved. Indeed, many protective strategies have been proposed with the aim of preemptively inducing tolerance against IRI or interfering with the pathways of injury and regeneration, either by inhibiting deleterious molecules or enhancing protective pathways. Thus, the focus of the special issue of HPB Surgery will be on the below-listed topics. Potential topics include, but are not limited to:

  • Surgical techniques
  • Pathophysiology
  • Diagnostic markers and predictors
  • Preconditioning (i.e., surgical, pharmacological)
  • Meta-analyses
  • Clinical trials

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/hpb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 453295
  • - Editorial

Ischemia/Reperfusion Injury in Liver Surgery and Transplantation

Peter Schemmer | John J. Lemasters | Pierre-Alain Clavien
  • Special Issue
  • - Volume 2012
  • - Article ID 236406
  • - Research Article

Ischemic Preconditioning of Rat Livers from Non-Heart-Beating Donors Decreases Parenchymal Cell Killing and Increases Graft Survival after Transplantation

Robert T. Currin | Xing-Xi Peng | John J. Lemasters
  • Special Issue
  • - Volume 2012
  • - Article ID 641982
  • - Research Article

C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation

Christoph Czerny | Tom P. Theruvath | ... | John J. Lemasters
  • Special Issue
  • - Volume 2012
  • - Article ID 783479
  • - Research Article

Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia

Arash Nickkholgh | Zhanqing Li | ... | Peter Schemmer
  • Special Issue
  • - Volume 2012
  • - Article ID 714672
  • - Research Article

Desferrioxamine Attenuates Pancreatic Injury after Major Hepatectomy under Vascular Control of the Liver: Experimental Study in Pigs

Panagiotis Varsos | Constantinos Nastos | ... | Nikolaos Arkadopoulos
  • Special Issue
  • - Volume 2012
  • - Article ID 480893
  • - Research Article

ICAM-1 Upregulation in Ethanol-Induced Fatty Murine Livers Promotes Injury and Sinusoidal Leukocyte Adherence after Transplantation

Tom P. Theruvath | Venkat K. Ramshesh | ... | John J. Lemasters
  • Special Issue
  • - Volume 2012
  • - Article ID 259512
  • - Research Article

Minocycline Decreases Liver Injury after Hemorrhagic Shock and Resuscitation in Mice

Christoph Czerny | Andaleb Kholmukhamedov | ... | John J. Lemasters
  • Special Issue
  • - Volume 2012
  • - Article ID 176723
  • - Review Article

Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology

Kilian Weigand | Sylvia Brost | ... | Martina Müller
  • Special Issue
  • - Volume 2012
  • - Article ID 720754
  • - Review Article

Anesthetic Considerations in Hepatectomies under Hepatic Vascular Control

Aliki Tympa | Kassiani Theodoraki | ... | Vassilios Smyrniotis
  • Special Issue
  • - Volume 2012
  • - Article ID 270372
  • - Research Article

Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811

Qinlong Liu | Hasibur Rehman | ... | Zhi Zhong

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