Phenotypic Diversity in GNAO1 Patients: A Comprehensive Overview of Variants and Phenotypes

<div>Classical view of G<i>α</i>o signaling. Overview of the different stages of the G<i>α</i>o activation cycle and the canonical signaling of GPCRs through G<i>α</i>o. Of note and not depicted: G<i>α</i>o likely performs also GPCR-independent functions like KEDLR-mediated activation of RAB4 that is independent of G<i>βγ</i> [<a href="/journals/humu/2023/6628283/#B57">57</a>].</div>

Human Mutation

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Figure 2

Figure 2: Phenotypic Diversity in GNAO1 Patients: A Comprehensive Overview of Variants and Phenotypes 