Table of Contents
International Journal of Bacteriology
Volume 2013, Article ID 204141, 15 pages
http://dx.doi.org/10.1155/2013/204141
Review Article

Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily

1QC Laboratory, Harvest and Post Harvest Technology Division, Central Institute of Fisheries Education (CIFE), Seven Bungalows, Versova, Andheri (W), Mumbai 400061, India
2Biology Department, Eastern New Mexico University, Portales, NM 88130, USA

Received 28 June 2013; Revised 29 September 2013; Accepted 8 October 2013

Academic Editor: Rodrigo E. Mendes

Copyright © 2013 Sanath Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial agents. Drug and multidrug resistant bacteria harbor several distinct molecular mechanisms for resistance. Bacterial antimicrobial agent efflux pumps represent a major mechanism of clinical resistance. The major facilitator superfamily (MFS) is one of the largest groups of solute transporters to date and includes a significant number of bacterial drug and multidrug efflux pumps. We review recent work on the modulation of multidrug efflux pumps, paying special attention to those transporters belonging primarily to the MFS.