Table of Contents
International Journal of Brain Science
Volume 2014, Article ID 217503, 14 pages
Review Article

On the Genesis of Neuroblastoma and Glioma

1Institut des Neurosciences de Montpellier, INSERM U1051, Hôpital St Eloi, 80 rue Augustin Fliche, 34091 Montpellier, France
2BetaInnov Research, Institut de Recherche en Biothérapie de Montpellier, Hôpital St Eloi, 80 rue Augustin Fliche, 34091 Montpellier, France

Received 20 September 2013; Accepted 29 December 2013; Published 26 March 2014

Academic Editor: João O. Malva

Copyright © 2014 Jan de Weille. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As the emergence of cancer is most frequent in proliferating tissues, replication errors are considered to be at the base of this disease. This review concentrates mainly on two neural cancers, neuroblastoma and glioma, with completely different backgrounds that are well documented with respect to their ontogeny. Although clinical data on other cancers of the nervous system are available, usually little can be said about their origins. Neuroblastoma is initiated in the embryo at a moment when the nervous system (NS) is in full expansion and occasionally genomic damage can lead to neoplasia. Glioma, to the contrary, occurs in the adult brain supposed to be mostly in a postmitotic state. According to current consensus, neural stem cells located in the subventricular zone (SVZ) in the adult are thought to accumulate enough genomic mutations to diverge on a carcinogenic course leading to diverse forms of glioma. After weighing the pros and cons of this current hypothesis in this review, it will be argued that this may be improbable, yielding to the original old concept of glial origin of glioma.