Protein Accession number Molecular function Biological process U87-MG-17AAG/U87-MG U87-MG-shhsp90α /U87-MG Proteins upregulated by inhibition of Hsp90 by 17AAG and shRNA targeted towards hsp90α HSP70-1 (homosapiens) gi
4529893 Chaperone activity Protein metabolism 7.8 1.3 Hexokinase 1, isoform CRA_d (homosapiens) gi
119574708 Catalytic activity Metabolism, energy pathways 4.5 1.9 Tumor rejection antigen (gp96) 1 variant (homosapiens) gi
62088648 Heat shock protein activity Protein metabolism 3.1 1.7 Vimentin variant 3 (homosapiens) gi
167887751 Structural constituent of cytoskeleton Cell growth and/or maintenance 2 1.2 Pyruvate kinase, muscle (homosapiens) gi
127795697 Kinase activity Metabolism, energy pathways 6.6 2.9 Vimentin variant 3 (homosapiens) gi
167887751 Structural constituent of cytoskeleton Cell growth and/or maintenance 3.9 1.4 Heat shock 70 kDa protein 8 isoform 2 (homosapiens) gi
24234686 Heat shock protein activity Protein metabolism 4.2 1.2 Chain A, Crystal Structure of Aldose Reductase complexed with Dichlorophenylacetic acid gi
119390284 Oxidoreductase activity Metabolism, energy pathway 2.8 1.2 Annexin I (homosapiens) gi
4502101 Calcium ion binding Cell communication, signal transduction 16.8 1.7 Glyceraldehyde-3-phosphate dehydrogenase (homosapiens) gi
31645 Catalytic activity Metabolism, energy pathway 8 1.9 Ubiquitin carboxyl-terminal Esterase L1 (ubiquitin thiolesterase), Isoform CRA_c (homosapiens) gi
119613387 Ubiquitin specific protease activity Protein metabolism 2.2 1 Heat shock protein 27 (homosapiens) gi
662841 Chaperone activity Protein metabolism 2.7 1.1 Heat shock protein 27 (homosapiens) gi
662841 Chaperone activity Protein metabolism 2.7 1.2 Actin related protein 2/3 complex Subunit 2 (homosapiens) gi
5031599 Cytoskeletal protein binding Cytoskeleton organization and biogenesis 2.9 1 Heat shock 70 kDa protein 8 isoform 2 variants (homosapiens) gi
62896815 Heat shock protein activity Protein metabolism 4.5 1.3 Proteins downregulated by inhibition of Hsp90 by 17AAG and shRNA targeted towards hsp90α X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70 kDa) (homosapiens) gi
169145198 DNA binding Regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolism, DNA repair. −3.7 −1.2 Vimentin (homosapiens) gi
62414289 Structural constituent of cytoskeleton Cell growth and/or maintenance −2.3 −3.4 Vimentin (homosapiens) gi
62414289 Structural constituent of cytoskeleton Cell growth and/or maintenance −2.1 −1.3 SERPINE1 mRNA binding protein 1 isoform 1 gi
66346679 RNA binding Regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolism. −2.2 −1.4 Calumenin isoform a precursor (homosapiens) gi
4502551 Calcium ion binding Cell communication, Signal transduction −1.9 −2.5 Phosphoglycerate kinase 1 (homosapiens) gi
4505763 Catalytic activity Metabolism, Energy pathways −1.2 −2 Aldolase A, fructose-bisphosphate, isoform CRA_b gi
119600342 Lyase activity Metabolism, Energy pathways −2 −1.6 Predicted Glyceraldehyde-3-phosphate Dehydrogenase-like 6 (homosapiens) gi
169208088 Catalytic activity Metabolism, Energy pathways −2.5 −1.8 Tropomyosin 4-anaplastic lymphoma kinase fusion protein (homosapiens) gi
13274400 Structural constituent of cytoskeleton Cell communication, Signal transduction −2 −1.4 Eukaryotic translation initiation factor 3, subunit 12 gi
10801345 Translation regulator activity Protein metabolism −2.7 −1.6 Transgelin 2 (homosapiens) gi
4507357 Unknown Unknown −3 −1 Chain A, Cyclophilin B complexed with (d-(Cholinylester)ser8)-Cyclosporin gi
1310882 Unknown Unknown −3.7 −1.8 Proteins differentially expressed by inhibition of Hsp90 by 17AAG and shRNA targeted towards hsp90α Collagen, type VI, alpha 1 precursor (homosapiens) gi
87196339 Extracellular matrix structural constituent Cell growth and/or maintenance 2.1 −1.5 Chain A, structure of human Annexin A2 in the presence Of calcium ions gi
56967118 Calcium ion binding Signal transduction, Cell communication 2.1 −1.1 Heat shock protein beta-1 (homosapiens) gi
4504517 Chaperone activity Protein metabolism 2.3 −1.2 Chain A, Human manganese superoxide dismutase mutant Q143n gi
2780818 Superoxide dismutase activity Cell proliferation, Anti-apoptosis, Cell growth and/or maintenance 2.7 −1.2 Chain A, crystal structure of Ca2+-bound form of Des3-23alg-2 gi
211939086 Unknown Apoptosis 2.3 −1.1 Transgelin 2 (homosapiens) gi
4507357 Unknown Unknown 2.4 −1.1
