Prenatal Curcumin Administration Reverses Behavioral and Neurochemical Effects and Decreases iNOS and COX-2 Expressions in Ischemic Rat Pups

Figure 2

Determination of dopamine (DA) and DOPAC concentrations (ng/g tissue) by HPLC (a) and (b), in striatal tissue from 10-day-old rat pups, at the 1st, 7th, and 14th days after the surgical procedure (SO = sham-operated and ISC = ischemic). The values are means ± SEM from 5 to 21 animals per group. DA - A. versus SO: 1st day ( ratio = 16.972, df = 9, ); 7th day ( ratio = 17.256, df = 13, ); 14th day ( ratio = 35.510, df = 31, ). B. versus ISC + C25: 7th day ( ratio = 7.093, df = 16, ). C. versus SC + C50: 1st day ( ratio = 6.137, df = 10, ); 7th day ( ratio = 3.986, df = 13, ); 14th day ( ratio = 2.633, df = 23, ). DOPAC - A. versus SO: 1st day ( ratio = 7.920, df = 10, ); 7th day ( ratio = 14.145, df = 12, ); 14th day ( ratio = 22.682, df = 32, ). B. versus ISC + C25: 7th day ( ratio = 3.846, df = 15, ); 14th day ( ratio = 6.736, df = 27, ). C. versus ISC + C50: 7th day ( ratio = 3.973, df = 12, ; 14th day ( ratio = 5.551, df = 20, ) (two-way ANOVA and multiple -tests of data).

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