Prenatal Curcumin Administration Reverses Behavioral and Neurochemical Effects and Decreases iNOS and COX-2 Expressions in Ischemic Rat Pups

Table 1

DOPAC/DA ratios in striatal tissues of sham-operated (SO) and ischemic rat pups (ISC) from untreated dams (ICUD) or from dams treated with curcumin (ICTD), at the doses of 25 or 50 mg/kg, in different postischemia times.

Group	SO	ICUD	ICTD 25	ICTD 50
1st day	0.60	1.19	0.66	0.95
7th day	0.82	0.72	1.02	0.85
14th day	0.66	0.55	0.49	0.41

Rat pups from untreated (ICUD) or curcumin (C, 25 or 50 mg/kg) treated dams (ICTD) were subjected to global cerebral ischemia (ISC), 10 days after birth, and euthanized for brain dissection and neurochemical determinations, at the 1st, 7th, and 14th postischemia days. The values are from 7 to 21 animals per group.