Research Article

Genomic Analysis of AZD1222 (ChAdOx1) Vaccine Breakthrough Infections in the City of Mumbai

Table 1

Clinical and demographic details of the cohort (n = 159).

Unvaccinated (n = 92)Vaccinated 1st dose (n = 29)Vaccinated 2nd dose (n = 38)

Median age (range)37.5 (6–77) years40 (20–81) years33 (9–62) years
Male:female1:11:90 : 6
Symptomatic (n, %)79 (85.9)29 (100%)36 (94.7%)
 Fever (n, %)60 (65.2%)24 (82.8%)20 (52.6%)
 Cough (n, %)35 (38%)13 (44.8%)17 (44.7%)
 Sore throat (n, %)17 (18.5%)6 (20.7%)14 (36.8%)
 Body ache (n, %)15 (16.3%)13 (44.8%)19 (50%)
 Breathlessness (n, %)14 (15.2%)9 (31%)4 (10.5%)
Comorbidities (n, %)39 (42.4%)12 (41.4%)7 (18.4%)
 Malignancies (n, %)27 (29.3%)1 (3.4%)1 (2.6%)
 Diabetes mellitus (n, %)8 (8.7%)4 (13.8%)2 (5.3%)
 Hypertension (n, %)7 (7.6%)5 (17.2%)3 (7.9%)
Distribution according to municipality
 Mumbai11 (11.9%)6 (20.7%)7 (18.4%)
 Palghar1 (1.1%)00
 Raigad57 (61.9%)19 (65.5%)22 (57.9%)
 Thane23 (25%)4 (13.8%)9 (23.7%)
Type of vaccine (total, AZD1222:BBV152)16 (<14 days after the first dose), 11 : 529, 24 : 538, 38 : 0
 14–20 days from the 1st dose6 (20.7%)
 21–28 days from the 1st dose4 (13.8%)
 28+ days from the 1st dose12 (65.5%)
 14–20 days from the 2nd dose6 (15.8%)
 21–28 days from the 2nd dose8 (21.1%)
 28+ days from the 2nd dose24 (63.2%)
SARS-CoV-2 genomic sequencing
 B.1.617.140 (43.5%)14 (48.3%)23 (60.5%)
 B.1.617.246 (50%)15 (51.7%)14 (36.8%)
 B.1.617.33 (3.2%)00
 B.1.1.71 (1.1%)00
 Others2 (2.2%)01 (2.6%)
CBC (data available in n=45)(n = 31)(n = 9)(n = 5)
 Median TLC x 10^9/L (range)5.23 (0.27–9.04)5.27 (3.39–14.98)5.17 (4.68–8.3)
 Median worst ALC x 109/L (range)0.89 (0.11–3.19)0.88 (0.36–1.2)0.9 (1.3–1.7)
Biochemical parameters (data available in n=45)(n = 31)(n = 9)(n = 5)
 Median worst CRP mg/L (range)2.15 (0.1–32.0)1.8 (0.5–16.22)2.0 (0.2–3.4)
 Median highest IL6 pg/mL (range)7.8 (0.7–8677)14.3 (0.4–69.2)8.3 (0.8–16.1)
 Median worst procalcitonin ng/mL (range)0.05 (0.05–151.5)0.05 (0.05–0.92)0.05 (0.05–0.05)
 Median worst fibrinogen mg/dL (range)345 (197–539)361 (248–613)349 (284–523)
 Median worst D-dimer ng/mL (range)219 (127–878)200 (148–522)213 (177–220)
Distribution according to the clinical outcome
 Not hospitalized (WHO score 1–2)51 (55.4%)17 (58.6%)29 (76.3%)
 Hospitalized, mild disease (WHO score 3–4)30 (32.6%)9 (31.0%)9 (23.7%)
 Hospitalized, severe disease (WHO score 5–7)7 (7.6%)3 (10.3%)0
 Death (WHO score 8)4 (4.3%)00