Pulmonologist-Administered Balanced Propofol Analgosedation during Interventional Procedures: An Italian Real-Life Study on Comfort and Safety

Table 5

Relation between propofol total dose and sedation depth, VAS, will of undergoing again to the procedure, minutes to reach the modified Aldrete score of ≥9, AEs.

Variable 1	Variable 2	Kendall correlation (τ)	CI (95%)		value
Propofol total dose (mg)^‡	RASS	−0.250	−0.348/−0.146		0.001
Propofol total dose (mg)^‡	VAS	0.108	0.002/0.212		0.144
Propofol total dose (mg)^‡	q.4^δ	−0.029	−0.138/0.080		0.704
Propofol total dose (mg)^‡	Min Aldrete	0.001	−0.106/0.105		0.993
		Pearson chi-squared (χ^2)
Variable 1	Variable 2	Coefficient		value
Propofol total dose (mg)^‡	AEs	2.259		0.32
Propofol total dose (mg)^‡	VFB route	3.089		0.21

RASS: Richmond Agitation Sedation Scale; VAS: Visual Analog Scale; ^δ: Question 4 of anonymous questionnaire: subjects’ will of undergoing the procedure again; min Aldrete: minutes to reach the modified Aldrete score of ≥9; AEs: adverse events/severe adverse events; VFB route: oral or nasal;^‡ grouped in classes: 20–50 mg; 51–80 mg; >80 mg. Kendal coefficient expresses the correlation between total dose and every single data detected for VAS, RASS, minute of the modified Aldrete score, and subject’s will of undergoing the procedure again. p value significance: 95%.