The Gut-Liver Axis in Nonalcoholic Fatty Liver Disease: Association of Intestinal Permeability with Disease Severity and Treatment Outcomes

Table 3

Correlations between D-lactate and clinical parameters in patients with NAFLD.

	D-lactate (U/L)
	r	value
Liver test parameters
ALT (U/L)	0.312	˂0.001
AST (U/L)	0.303	˂0.001
GGT (U/L)	0.190	0.017
TBIL (μmol/L)	0.214	0.004
DBIL (μmol/L)	0.130	0.081
IBIL (μmol/L)	0.247	0.001
Liver ultrasonographic parameters
LSM (kPa)	0.049	0.515
FAP (dB/m)	0.252	0.001
Metabolic parameters
TG (mmol/L)	0.173	0.021
TC (mmol/L)	0.117	0.121
HDL (mmol/L)	0.066	0.384
LDL (mmol/L)	0.096	0.203
HOMA-IR value	0.100	0.173
Intestinal parameters
DAO (U/L)	0.218	0.002
LPS (U/L)	0.132	0.069

ALT, alanine transaminase; AST, aspartate transaminase; DAO, diamine oxidase; DBIL, direct bilirubin; FAP, fat attenuation parameter; GGT, gamma-glutamyl transpeptidase; HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; IBIL, indirect bilirubin; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LSM, liver stiffness measurement; NAFLD, nonalcoholic fatty liver disease; TBIL, total bilirubin; TC, total cholesterol; TG, triglyceride. Significant P values are indicated in bold font.