Statins Are Associated with Improved Survival of Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Table 1

Literature search and characteristics of the included studies.

Study	Design	Country	Statin type	Sample size		Age (year, mean, or median)		Gender, male (%)		Previous therapy	Follow-up duration
				Statin users	Nonstatin users	Statin users	Nonstatin users	Statin users	Nonstatin users
Kim et al. 2014	RCT	Korea	Simvastatin	120	124	53.5 (20–78)	54.5 (24–79)	91	85	Neoadjuvant therapy/gastrectomy/adjuvant therapy	5.4 years
Bujanda et al. 2016	Prospective cohort study	Spain	Pravastatin	20	40	65.4 (11.7)	66.3 (12.8)	15	23	Surgery/chemotherapy/radiotherapy	4–6 years
Spence et al. 2019 (English cohort)	Retrospective cohort study	UK	Statin prescriptions	650	1741	72.5 (8.9)	69.8 (12.8)	476	1141	Surgery/chemotherapy/radiotherapy	17 years
Spence et al. 2019 (Scottish cohort)	Retrospective cohort study	UK	Statin prescriptions	370	552	72.4 (9)	68.3 (13.1)	370	552	Surgery/chemotherapy/radiotherapy	17 years
Yang et al. 2020 (PSM)	Retrospective cohort study	Taiwan	Statin prescriptions	367	1468	64.3 (10.5)	64.1 (12.6)	208	857	Surgery/chemotherapy	14 years
Nam et al. 2014	Case-control	Korea	Statin prescriptions	65	176	—	—	18	42	Radical gastrectomy	3.5 years