The Different Effects of Direct Bilirubin on Portopulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension

Table 3

Correlation between PVR and laboratory variables, liver function test, and therapies in POPH and IPAH.

	POPH		IPAH
	r		r
Liver function test
Total bilirubin	−0.394	0.031	0.218	0.003
Direct bilirubin	−0.364	0.048	0.178	0.018
AST	−0.136	0.474	0.139	0.066
D-dimer	0.009	0.964	0.016	0.913
Blood cell counts
WBC	0.275	0.142	0.179	0.117
Neutrophils	0.394	0.031	0.107	0.167
NT-proBNP	0.203	0.299	0.438	<0.001
PCO2	0.014	0.940	0.004	0.976
Target therapies	−0.076	0.690	0.133	0.076
MELD scores (per unit)	−0.243	0.195	—	—

Data were conducted via Pearson or Spearman correlation analyses. PVR, total bilirubin, direct bilirubin, AST, D-dimer, blood cell counts, NT-proBNP, and PCO₂ were regarded as continuous variables. Target therapies and MELD scores were deemed as categorical variables. PVR, pulmonary vascular resistance; POPH, portopulmonary hypertension; IPAH, idiopathic pulmonary arterial hypertension; AST, aspartate aminotransferase; WBC, white blood cell; NT-proBNP, N-terminal pro brain natriuretic peptide; PCO₂, partial pressure of carbon dioxide; MELD scores, model for end-stage liver disease scores; —, not applicable.