Research Article
The Effects of Probiotics and Omega-3 Fatty Acids in Liver Steatosis Induced in Rats by High-Fructose Corn Syrup
Table 7
Scoring the level of steatosis in liver tissue of rats.
| Microscopic scoring | Control group (n = 8) | HFCS group (n = 8) | HFCS + omega-3 fatty acids group (n = 8) | HFCS + probiotic group (n = 8) | HFCS + omega-3 fatty acids + probiotic group (n = 8) | | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD |
| Steatosis (0–3) | 0.18 ± 0.11 | 2.05 ± 0.17a3 | 0.95 ± 0.12a3,b3 | 0.81 ± 0.10a3,b3,c2 | 0.72 ± 0.11a3,b3,c2,d1 | 0.001 | (0.10–0.42) | (1.80–2.33) | (0.84–1.24) | (0.65–1.02) | (0.62–0.98) | | Lobular inflammation (0–3) | 0.00 ± 0.00 | 1.08 ± 0.12a3 | 0.21 ± 0.10a3,b3 | 0.13 ± 0.05a3,b3 | 0.11 ± 0.02a3,b3,c1 | 0.001 | (0.00–0.00) | (0.92–1.31) | (0.11–0.43) | (0.10–0.27) | (0.10–0.17) | | Hepatocellular ballooning (0–2) | 0.00 ± 0.00 | 0.27 ± 0.06a3 | 0.00 ± 0.00b3 | 0.00 ± 0.00b3 | 0.00 ± 0.00b3 | 0.001 | (0.00–0.00) | (0.21–0.43) | (0.00–0.10) | (0.00–0.00) | (0.00–0.00) | | NAS(0–8) | 0.18 ± 0.11 | 3.41 ± 0.24a3 | 1.23 ± 0.13a3,b3 | 0.94 ± 0.12a3,b3,c3 | 0.84 ± 0.13a3,b3,c3 | 0.001 | (0.10–0.42) | (3.10–3.73) | (1.11–1.45) | (0.76–1.15) | (0.73–1.11) | |
|
|
Kruskal–Wallis H-test. Mann–Whitney U test. aFor the control group, ≤ 0.05 a1, ≤ 0.01 a2, ≤ 0.001 a3. bFor the HFCS group, ≤ 0.05 b1, ≤ 0.01 b2, ≤ 0.001 b3. cFor the HFCS + omega-3 fatty acids group, ≤ 0.05 c1, ≤ 0.01 c2, ≤ 0.001 c3. dFor the HFCS + probiotic, ≤ 0.05 d1, ≤ 0.01 d2, ≤ 0.001 d3. Bold shows statistically significant values. |